This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. Thei...

Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used classes of medications to treat pain and inflammation. However, gastrointestinal complications associated with NSAIDs are prevalent, largely due to the frequent use of these agents. Adverse events associated with NSAIDs include minor side effects, such as dyspepsia, as well as serious complications, such a...

background: sodium hypochlorite is found in bleaching agents used to cleaning dishes and bleach laundry. the ingestion of sodium hypochlorite causes acute corrosive esophagitis and gastritis. in establishing the diagnosis and therapeutic approach of acute corrosive poisonings, the upper endoscopy has great importance. the aim of this study was to determine predictive factors of gastrointestinal...

INTRODUCTION Dysbiosis is associated with a number of gastrointestinal and systemic disorders. There is a need for selectively acting antimicrobial agents capable of inhibiting the growth of potentially pathogenic microorganisms, or those found to be out of balance, while not negatively impacting the bulk gastrointestinal tract microflora. OBJECTIVE The purpose of this in vitro study is to ex...

Gastrointestinal damage is generated by a wide range of harmful agents, and the result activation inflammatory, oxidant cytotoxic mechanisms, that together overwhelm “mucosa defense” gastrointestinal (GI) tract. It currently known mechanisms which gastric are slightly different from those generate intestinal damage. The treatments available on market such as citoprotectors, use selective Cicloo...

Venous thromboembolism (VTE) is a frequent complication of gastrointestinal cancers that increases morbidity and may impact mortality. Low-molecular-weight heparins (LMWHs) and vitamin K antagonists (VKAs) are standard anticoagulation options for the ambulatory gastrointestinal cancer patient with VTE, but both of these agents are challenging to use for various reasons. Novel oral anticoagulant...

The oral bioavailability of many lipophilic bioactive agents (pharmaceuticals and nutraceuticals) is limited due to various physicochemical and physiological processes: poor release from food or drug matrices; low solubility in gastrointestinal fluids; metabolism or chemical transformation within the gastrointestinal tract; low epithelium cell permeability. The bioavailability of these agents c...

Gastrointestinal stromal tumours (GIST) comprise a heterogeneous group of the most common mesenchymal neoplasms gastrointestinal tract. The majority GIST are induced by activating, mutually exclusive mutations two genes – KIT and PDGFRA (platelet-derived growth factor receptor-alpha). However, approximately 10–15% GISTs lack oncogenic or these often called “wild type” (WT) GISTs. SDH-deficient ...