Abstract Background/aims Functional dyspepsia (FD) is often comorbid with sleep disturbance. However, it not fully understood how disturbance affects the pathophysiology of FD. We aimed to investigate relationship between FD and Methods prospectively enrolled 20 patients December 2018 July 2019. Patients took aids for 4 weeks filled out questionnaires before after taking aids. Pittsburgh Sleep ...

An internet-delivered cognitive behavioral treatment (ICBT) based on systematic exposure exercises has previously shown beneficial effects for patients with irritable bowel syndrome (IBS). Exposure exercises may be perceived as difficult for patients to perform because of the elicited short-term distress and clinicians may be reluctant to use these interventions. The aim of this study was to co...

Objectives: To evaluate the gastrointestinal safety and efficacy of the COXinhibiting nitric oxide donator (CINOD) AZD3582 [4-(nitrooxy)butyl-(2S)-2-(6methoxy-2 naphthyl)propanoate] in patients with hip or knee osteoarthritis. Methods: Patients (n=970) enrolled into a double-blind study were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily or placebo twice daily. Th...

BACKGROUND The purpose of this study was to assess changes in gastrointestinal symptom severity in patients with autoimmune disease who were switched from mycophenolate mofetil to enteric-coated mycophenolate sodium (EC-MPS). METHODS In this national, explorative, single-arm study, 111 patients were enrolled and switched to equimolar EC-MPS at baseline. The primary endpoint was change in the ...

Background: Helicobacter pylori (H. pylori) infection has become a remarkable worldwide health problem. The eradication of H. challenge. Probiotics have proven beneficial in reducing the side effects and increases patient compliance. Lactobacillus reuteri (L. reuteri) is frequently used probiotic considered safe for human consumption. aim this study was to compare effectiveness conventional ant...

BACKGROUND & AIMS Rebound acid hypersecretion (RAHS) has been demonstrated after 8 weeks of treatment with a proton-pump inhibitor (PPI). If RAHS induces acid-related symptoms, this might lead to PPI dependency and thus have important implications. METHODS A randomized, double-blind, placebo-controlled trial with 120 healthy volunteers was conducted. Participants were randomized to 12 weeks o...

BACKGROUND It is unknown whether symptoms in non-coeliac patients (non-CD) meeting clinical diagnostic criteria for noncoeliac gluten sensitivity (NCGS) are specifically triggered by gluten. AIM To assess gluten sensitivity in patients diagnosed with NCGS. METHODS We studied 35 non-CD subjects (31 females) that were on a gluten-free diet (GFD), in a double-blind challenge study. Participant...

BACKGROUND Partial response to proton pump inhibitor (PPI) therapy poses a healthcare challenge. This study aimed to compare symptom profiles in partial PPI responders and treatment-naïve patients with gastroesophageal reflux disease (GERD). METHODS A post hoc analysis of data from two studies was performed. Partial PPI responders with GERD (n = 580; NCT00703534) had frequent (≥ 3 days/week) ...

Objective Gender differences, including differences in the prevalence, subtypes and the effectiveness of treatment, are generally recognized in irritable bowel syndrome (IBS). Although serotonin type 3 receptor (5-HT3R) antagonists appear to be more effective in women with diarrhea predominant IBS (IBS-D) than they are in men, the mechanisms underlying these effects remain unclear. The aim of t...

BACKGROUND Health-related quality of life (HRQoL) is impaired in untreated patients with gastroesophageal reflux disease (GERD). In the absence of an objective marker such as erosions, assessment of treatment efficacy can be based on symptoms and HRQoL. OBJECTIVE To evaluate changes in HRQoL during treatment with pantoprazole or nizatidine in patients with GERD. METHODS This was a prospecti...