PURPOSE This study investigated the correlation between the relative afferent pupillary defect (RAPD) and retinal nerve fiber layer thickness (RNFLT) in optic neuropathy. METHODS RAPD assessment was performed using a log unit neutral density filter bar. Spectral domain optical coherence tomography RTVue-100 (Optovue) was used to examine the subjects. The optic nerve head pattern (ONH) was sub...

Incorporation of global climate change (GCC) effects into assessments of chemical risk and injury requires integrated examinations of chemical and nonchemical stressors. Environmental variables altered by GCC (temperature, precipitation, salinity, pH) can influence the toxicokinetics of chemical absorption, distribution, metabolism, and excretion as well as toxicodynamic interactions between ch...

We examine the issues involved in producing a backend for the GNU Compiler Collection (GCC) that targets the .NET Common Language Runtime. We describe a simple back-end that is written in standard GCC style, which interfaces with the register transfer language GCC intermediate representation. We demonstrate that this simple .NET back-end is able to compile an appreciable subset of the C languag...

The GCC free compiler is a very large software, compiling source in several languages for many targets on various systems. It can be extended by plugins, which may take advantage of its power to provide extra specific functionality (warnings, optimizations, source refactoring or navigation) by processing various GCC internal representations (Gimple, Tree, ...). Writing plugins in C is a complex...

PURPOSE Recurrence risk assessment to make treatment decisions for early-stage colon cancer patients is a major unmet medical need. The aim of this retrospective multicenter study was to evaluate the clinical utility of guanylyl cyclase C (GCC) mRNA levels in lymph nodes on colon cancer recurrence. METHODS The proportion of lymph nodes with GCC-positive mRNA (LNR) was evaluated in 463 untreat...

This paper introduces the MELT framework and domain-specific language to extend the GCC compiler. It explains the major internal representations (Gimple, Tree-s, . . . ) and the overall organization of GCC. It shows the major features of MELT and illustrates why extending and customizing the GCC compiler using MELT is useful (for instance, to use GPGPUs thru OPENCL). It gives some concrete advi...

The Graph-based Convex Clustering (GCC) method has gained increasing attention recently. The GCC method adopts a fused regularizer to learn the cluster centers and obtains a geometric clusterpath by varying the regularization parameter. One major limitation is that solving the GCC model is computationally expensive. In this paper, we develop efficient graph reduction techniques for the GCC mode...

The GCC free compiler is a very large software, compiling source in several languages for many targets on various systems. It can be extended by plugins, which may take advantage of its power to provide extra specific functionality (warnings, optimizations, source refactoring or navigation) by processing various GCC internal representations (Gimple, Tree, ...). Writing plugins in C is a complex...

Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylase (PCC). Here we report the crystal structure of the 750-kDa α6β6 holoenzyme o...

BACKGROUND Screening programmes for contralateral carcinoma in situ (CIS) testis in patients with unilateral germ-cell cancer (GCC) have never been evaluated. We investigated the effect of screening for contralateral CIS in a large nation-wide, population-based study. PATIENTS AND METHODS A contralateral single-site biopsy was offered to 4130 patients in whom GCC had been diagnosed in 1984-20...