background: the most frequently used spermicide nonoxynol-9 (n-9) in the clinic alters the vaginal flora, which will result in an increased risk of opportunistic infection. so development of a novel spermicidal and microbicidal drug appears to be inevitable. vaginal local immune is an important part of vaginal flora. secretory leukocyte protease inhibitor (slpi), surfactant proteins d (sp-d), a...

The objective of this work was to develop bioadhesive topical gel of Aceclofenac with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 = X1) and hydroxypropylmethyl cellulose K100 M (HPMC = X2)] on the bioadhesive character of gel, rheological property o...