Polymeric micelles receive considerable attention as drug delivery vehicles, depending on the versatility in drug solubilization and targeting therapy. However, their use invariably suffers with poor stability both in in vitro and in vivo conditions. Here, we aimed to develop a novel nanocarrier (micellar emulsions, MEs) for a systemic delivery of genistein (Gen), a poorly soluble anticancer ag...

The National Renewable Energy Laboratory (NREL) evaluated the performance of diesel, compressed natural gas (CNG), and hybrid electric (equipped with BAE Systems’ HybriDrive propulsion system) transit buses at New York City Transit (NYCT). CNG, Gen I and Gen II hybrid electric propulsion systems were compared on fuel economy, maintenance and operating costs per mile, and reliability. These comp...

Breast cancer risk is highly modifiable by diet; however, mechanisms underlying dietary protection against mammary tumorigenesis remain poorly understood. A proportion of breast carcinomas is associated with deregulation of beta-catenin stability and amplification of c-Myc expression. We recently showed that dietary exposure to the soy isoflavone genistein (Gen) inhibited Wnt transduction in ra...

How do we reconcile Gen 1 with science? Three modern myths often interfere with understanding Gen 1. We propose to uncover these myths, in order to remove obstacles to understanding Gen 1. Rather than beginning with the myths immediately, let us first consider one strand in contemporary interpretation. This approach begins by reading Gen 1 within its ancient Near Eastern context. It compares an...

How do we reconcile Gen 1 with science? Three modern myths often interfere with understanding Gen 1. We propose to uncover these myths, in order to remove obstacles to understanding Gen 1. Rather than beginning with the myths immediately, let us first consider one strand in contemporary interpretation. This approach begins by reading Gen 1 within its ancient Near Eastern context. It compares an...

Studies of developmental eff ects of mixtures of endocrine disrupters on the male reproductive system are of great concern. In this study, the reproductive eff ects of the co-administration of di-2-(ethylhexyl) phthalate (DEHP) and genistein (GEN) during pregnancy and lactation were studied in male rat off spring. Pregnant Sprague-Dawley rats were gavaged from gestation day 3 to postnatal day 2...

Genistein (Gen) has been reported as a protective factor against breast cancer. However, the molecular mechanism by which Gen elicits its effects on triple-negative breast cancer cells has not been fully elucidated. In our study, the breast cancer cell line MDA-MB-231 was selected to determine the action of Gen on triple-negative breast cancer cells. MTT assay, flow cytometric analysis, siRNA t...

The receptor (R) for epidermal growth factor (EGF) is expressed at high levels on human breast cancer cells and associates with ErbB2, ErbB3, and Src proto-oncogene family protein tyrosine kinases (PTKs) to form membrane-associated PTK complexes with pivotal signaling functions. Recombinant human EGF was conjugated to the soybean-derived PTK inhibitor genistein (Gen) to construct an EGF-R-direc...

One new subfamily, four new genera and 10 new species of Psychodidae are described from Burmese amber which significantly increases our knowledge about this group in the Cretaceous. Protopsychodinae n. subfam. probably represents the oldest known ancestor of modern Psychodinae and includes three species within two genera: Datzia setosa gen. et sp. n., Datzia bispina gen. et sp. n., and Mandalay...