cancer, with a high rate of mortalities worldwide, pose a major threat to human health. although family history accounts for at least 5-10% of all cancers, it is conferred to be as a significant risk of developing cancer. recently, application of high speed and low cost high-throughput nucleotide sequencing technologies has provided an opportunity to assess cancer risk in at risk healthy indivi...

Dieser Erfahrungsbericht schildert Erfahrungen mit der Grundausbildung in Programmiersprachen. Soweit es ging, konnten Studenten aktiv lernen. Auch die Leistungskontrolle sollte einen aktiven Charakter bekommen: gleichzeitig von den Studenten aktiv erlebt und gestaltet werden, ihnen aber auch Feedback geben und am Ende benotet werden. Dabei erwies sich die klassische Klausur als ungeeignet. Der...

BACKGROUND Because common diseases are caused by complex interactions among many genetic variants along with environmental risk factors, very large sample sizes are usually needed to detect such effects in case-control studies. Nevertheless, many genetic variants act in well defined biologic systems or metabolic pathways. Therefore, a reasonable first step may be to detect the effect of a group...

As genotyping and genetic testing become more sophisticated, accessible, and costeffective, these tools hold great promise for predicting and improving responses to medications.