Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy today. As per American Diabetes Association (ADA) 2022, latest definition GDM diagnosed in second or third trimester that was not clearly overt prior to gestation. Blood sugar more than normal and less first defined as hyperglycemia early pregnancy. has been associated with adverse effects outcomes such pre...

Pregnancy induces progressive changes in maternal carbohydrate metabolism. As pregnancy advances insulin resistance and diabetogenic stress due to placental hormones necessitate compensatory increase in insulin secretion. When this compensation is inadequate gestational diabetes develops. Pregnancy that occurs in a woman who already has diabetes is termed ‘Pre-Gestational Diabetes Mellitus’. Bo...

Background: Ramadan fasting for pregnant women with diabetes remains controversial and underreported. The objective of this study was to determine the glycemic control in pregnant diabetic women on insulin who fasted during Ramadan. Methods: This was a retrospective study carried out over a period of three years including pregnant diabetic women, who were on short-acting, intermediate-a...

Physical activity and dietary advice represent the first choice and they are the most studied as well. They represent a non-pharmacological option and have a positive impact on insulin resistance although they do not seem to prevent the gestational diabetes onset.The preconceptional use of metformin in women with polycystic ovary syndrome protects the pancreatic beta cell reserve preventing or ...

AIMS/INTRODUCTION Variants in cell cycle regulation genes, CDKAL1 and CDKN2A/2B, have been suggested to be associated with type 2 diabetes, and also play a role in insulin procession in non-diabetic European individuals. Rs7754580 in CDKAL1 and rs7020996 in CDKN2A/2B were found to be associated with gestational diabetes in Chinese individuals. In order to understand the metabolism mechanism of ...

OBJECTIVE To compare perinatal outcome and glycaemic control in two groups of pregnant diabetic patients receiving two insulin regimens. DESIGN Randomised controlled open label study. SETTING University affiliated hospital, Israel. PARTICIPANTS 138 patients with gestational diabetes mellitus and 58 patients with pregestational diabetes mellitus received insulin four times daily, and 136 p...

OBJECTIVE This study was designed to compare glucose, lipids, and C-reactive protein (CRP) in women with gestational diabetes mellitus treated with metformin or insulin and in cord plasma of their offspring and to examine how these markers relate to infant size at birth. RESEARCH DESIGN AND METHODS Women with gestational diabetes mellitus were randomly assigned to metformin or insulin in the ...

The case of a woman, who developed gestational diabetes at six weeks in two successive pregnancies, is reported. She was in the high risk group to develop gestational diabetes. The first pregnancy terminated in abortion at 10 weeks. In the second pregnancy, institution of insulin therapy at diagnosis was associated with a successful outcome. This case highlights the need for screening for gesta...