Choriocarcinoma is an aggressive malignant disease that originates in the trophoblastic cells of the placenta, characterized by early hematogenous spread to the lungs. It belongs to the far spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumor. It is a hypervascular tumor composed of sheets of malignant cytotrophoblast and syncytiotrophoblast metastasizing hematogenou...

BACKGROUND Although the morphological features characteristic of products of conception specimens including molar pregnancies are well described, substantial histopathological similarities are observed between the different entities, especially in cases of early pregnancies. Furthermore, there are no current solid criteria that could predict cases with progression to persistent gestational trop...

OBJECTIVE The goal of this study was to investigate whether gestational trophoblastic disease (GTD) and healthy pregnancy differ with respect to complete blood count parameters and these parameters can be used both to explain the pathophysiologic mechanisms and differentiate the two conditions from each other. METHODS The data obtained from 37 women with GTD and 61 healthy pregnancies (contro...

Background: Gestational trophoblastic diseases (GTD) are important and interesting part of gynecological oncology. Women diagnosed with GTD should be counseled that about 8% become malignant GTN is a significant cause morbidity, fertility loss unfortunately mortality in young women. All form produce B- hCG monitoring this hormone precise biomarker for screening, diagnosis, therapeutic response ...

BACKGROUND The aim of the study was to record the incidence of treatment for infertility prior to development of gestational trophoblastic disease (GTD). METHODS AND RESULTS A retrospective analysis was undertaken of 231 consecutive women receiving chemotherapy for persistent GTD at Weston Park Hospital, Sheffield, from 1991 to 2001. Three patients in this group had received treatment for inf...

Objective. Gestational Trophoblastic Disease (GTD) management requires clear guidelines for diagnosis, treatment, and follow-up. Unequal management skills among practitioners, inadequate treatment, irregular surveillance, and drop-out are common in resource-limited settings and can lead to life-threatening complications and morbidities. To address these challenges, we implemented a GTD Manageme...

Gestational trophoblastic disease (GTD) comprises a spectrum of interrelated diseases including partial and complete molar pregnancy and choriocarcinoma with varying propensity for invasion and metastasis [1—4]. Despite the presence of widespread metastases, persistent gestational trophoblastic neoplasia (GTN) is highly curable with chemotherapy [2—6]. However, psychological shock is anticipate...

Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal proliferation of trophoblastic cells. GTDs encompass hydatidiform moles (HMs) and gestational trophoblastic neoplasia (GTN). GTNs are a group of malignant diseases that require chemotherapy, or more aggressive treatment. There is a requirement for more tumor markers to predict the development of GT...

placental site trophoblastic tumor (pstt) is a very rare variant of gestational trophoblastic tumor. it can occur after normal termination of pregnancy or spontaneous abortion and ectopic or molar pregnancy. there is a wide range of clinical manifestations from a benign condition to an aggressive disease with fatal outcome. one of the most important characteristics of pstt, unlike other forms o...

OBJECTIVES Gestational Trophoblastic Disease (GTD) comprises a group of disorders that derive from the placenta. Even if full recovery is generally expected, women diagnosed with GTD have to confront: the loss of a pregnancy, a potentially life-threatening diagnosis and delays in future pregnancies. The aim of the study is to evaluate the psychological impact of GTD, focusing on perceived ferti...