In the present study, the effects of chronic ethanol (ETOH) treatment on the glial fibrillary acidic protein (GFAP) immunoreactivity was investigated in adult rat brains. ETOH were administered as increasing concentrations of 2.4%-7.2% (v/v) gradually for 21 days. Immunocytochemistry revealed that chronic-ETOH treatment increased synthesis of GFAP. The increase in the diameter and the number of...

Following brain injury or neurodegenerative disease, successful regeneration requires orchestrated migration of neurons and reformation of long-distance communication fibres, or axons. Such extensive regeneration does not occur in the mature brain; however, during embryonic development, pathways formed by glial cells extend several millimeters (mm) to create 'living scaffolds' for targeted neur...

to study the immunohistochemical pattern of cd 117, glial fibrillary acidic protein (gfap), smooth muscle actin (sma) and cd 43 in pleomorphic adenoma (pa), adenoid cystic carcinoma (adcc) and polymorphous low grade adenocarcinoma (plga) of minor salivary glands.twenty cases of pa, 20 cases of adcc and 10 cases of plga were retrieved from record files along with their paraffin blocks at armed f...

To investigate the structural role of glial fibrillary acidic protein (GFAP) in vivo, mice carrying a null mutation in GFAP were generated. In 7/14 mutant animals older than 18 months of age, hydrocephalus associated with white matter loss was detected. Mutant mice displayed abnormal myelination including the presence of actively myelinating oligodendrocytes in adults, nonmyelinated axons in op...

We have previously reported that dietary tryptophan (TRP) restriction in a rat crucial postnatal developmental stage induces depression-like behavior and alters dendritic spine density in CA1 pyramidal neurons and granule cells of the hippocampus. Due to astrocyte involvement in critical brain mechanisms, it seems worth to investigate possible adaptive changes in the glial population with TRP r...

Although posttraumatic stress disorder (PTSD) is characterized by traumatic memories or experiences and increased arousal, which can be partly alleviated by antidepressants, the underlying cellular mechanisms are not fully understood. As emerging studies have focused on the critical role of astrocytes in pathological mood disorders, we hypothesized that several 'astrocyte-related' mechanisms un...

Astrocytes in the adult cat retina were stained by immunocytochemical localization of glial fibrillary acidic protein (GFAP), a major constituent of the astrocytic intermediate filaments. Their density in whole mounted retinae showed a peak of about 2000 astrocytes/mm at the optic nerve head and dropped to approximately 200 astrocytes/mm in the far periphery. At the central area a prominent loc...

Astrocytes in the adult cat retina were stained by immunocytochemical localization of glial fibrillary acidic protein (GFAP), a major constituent of the astrocytic intermediate filaments. Their density in whole mounted retinae showed a peak of about 2000 astrocytes/mm2 at the optic nerve head and dropped to approximately 200 astrocytes/mm2 in the far periphery. At the central area a prominent l...

Astrocytic tumors, particularly gliosarcoma, may contain epithelial features in the form of trabecular, adenoid, papillary arrangement, and squamous metaplasia. A case of gliosarcoma with unusual epithelial feature is described. The patient was a 60-year-old male with frequent seizures. The mass was 4 cm and in the left frontal lobe. Trabecular or rarely adenoid arrangement of neoplastic astroc...

Hippocalcin (Hpca) is a neuronal calcium sensor protein expressed in the mammalian brain. However, its function in neural stem/precursor cells has not yet been studied. Here, we clarify the function of Hpca in astrocytic differentiation in hippocampal neural precursor cells (HNPCs). When we overexpressed Hpca in HNPCs in the presence or absence of bFGF, expression levels of nerve-growth factors...