CDCA7 is a copy number amplification gene that promotes tumorigenesis. However, the clinical relevance and potential mechanisms of in glioma are unclear. expression level data were obtained from Chinese Glioma Genome Atlas (CGGA) The Cancer (TCGA) databases, enriched genes related signaling pathways explored. Data on CDCA7-related nine marker ferroptosis retrieved protein–protein interaction (P...

PURPOSE AHNAK is originally identified as a giant protein based on the estimated size of approximately 700 kDa. The aim of this study is to identify the role of AHNAK in the pathogenesis of glioma. METHODS We tested AHNAK mRNA level in a panel of six human glioma cell lines, and in 30 cases of normal brain tissues and 73 cases of glioma tissue samples using a qRT-PCR method. Further, we analy...

The aim of the present study was to investigate the role of cortactin in the infiltrative behavior of glioma cells and the potential mechanism of cortactin in promoting the migration and invasion of glioma cells. The expression of cortactin was detected by immunohistochemistry in 40 human glioma specimens and 8 non-tumor brain specimens. U251, LN229 and SNB19 glioma cells were employed for the ...

INTRODUCTION Glioma is one of the most common and most aggressive brain tumors in humans. The molecular and cellular mechanisms responsible for the onset and the progression of glioma are elusive and controversial. Centrosomal protein of 55 (CEP55) was initially described as a highly coiled-coil protein that plays critical roles in cell division, but was recently identified as being overexpress...

Glioma is among the deadliest tumors worldwide. Despite its relative low onset incidence, glioma, especially malignant glioma, causes high mortality. Due to the utmost aggressiveness of tumor cells, malignant glioma is almost incurable by conventional therapeutic approaches. Finding new molecular targets, which are responsible for tumor progression, can amplify our understanding about malignant...

Malignant glioma is the most common and destructive form of primary brain tumor. Along with surgery and radiation, chemotherapy remains as the major treatment modality. The emergence of drug resistance, however, often leads to a therapeutic failure in the treatment of glioma, precluding long-term survival of the patients. A proteomic approach has recently been adapted for the mechanistic analys...

PURPOSE Cancer stem cells have recently been thought to be closely related to tumor development and reoccurrence. It may be a promising way to cure malignant glioma by using glioma stem cell-targeted dendritic cells as a tumor vaccine. In this study, we explored whether pulsing dendritic cells with antigens of glioma stem cells was a potent way to induce specific cytotoxic T lymphocytes and ant...

Glioma is a highly invasive and frequently occurring type of brain malignancy in the central nervous system. The prognosis often poor for glioma patients, despite substantial advances diagnosis therapeutic approaches. breakthrough discoveries oncoimmunology have led to innovative efficacious immunotherapeutic strategies treat or even cure cancer patients; however, efficacy immunotherapy disappo...

Abstract Recent evidence indicates that diffuse gliomas engage with neurons at the single-unit and circuit level through differing mechanisms. Certain malignant form glioma-neuron excitatory glutamatergic synapses modulate neuron-neuron activity-dependent paracrine signaling, while others establish glioma-glioma connections via tumor microtubes. It is therefore possible remodel neuronal circuit...

Microenvironmental regulation of cancer stem cells (CSCs) strongly influences the onset and spread of cancer. The way in which glioma cells interact with their microenvironment and acquire the phenotypes of CSCs remains elusive. We investigated how communication between vascular endothelial cells and glioma cells promoted the properties of glioma stem cells (GSCs). We observed that CD133(+) GSC...