introduction: repeated hyperglycemia play an important role in the development of atherosclerosis in diabetic patients. endothelium is the organ of the first-line defense against atherosclerosis and nitric oxide has a major role in this task. the aim of this study was to determine changes in plasma nitric oxide metabolites concentration during glucose tolerance test in type 2 diabetic rats. met...

background impaired fasting glucose (ifg), and impaired glucose tolerance (igt) are two prediabetes conditions which have some correlation with macrovascular disorders. the risk of microvascular complications in these groups is not clear. objectives the prevalence of albuminuria in subjects with ifg and igt was evaluated in the present study. patients and methods in this study three groups of s...

Atp10c is a strong candidate gene for diet-induced obesity and type 2 diabetes. To identify molecular and cellular targets of ATP10C, Atp10c expression was altered in vitro in C2C12 skeletal muscle myotubes by transient transfection with an Atp10c-specific siRNA. Glucose uptake assays revealed that insulin stimulation caused a significant 2.54-fold decrease in 2-deoxyglucose uptake in transfect...

Sodium glucose transporter-2 inhibitors (SGLT2-i) are a class of medicine that have been recently acknowledged and approved for management Type-2 Diabetes Mellitus (T2DM). They distinct encouraging extra-pancreatic glucuretic role has clinically applied blood sugar management. Reports published multiple side effects including ketoacidosis & ketonuria induced by SGLT2-i. This endeavor delves...