Convulsions due to vitamin B-6 deficiency in humans can be controlled by the administration of pyridoxine, and the symptoms subside rapidly (Coursin, 1954). If derangement of y-aminobutyric acid metabolism were responsible for these convulsions, it would be expected that a return to normal y-aminobutyric acid metabolism occurs very rapidly after the pyridoxine administration. In vitamin B-&defi...

Abstract Background Gamma-aminobutyric acid (GABA) is an important bio-product used in pharmaceuticals and functional foods as a precursor of the biodegradable plastic polyamide 4. Glutamate decarboxylase (GAD) converts l -glutamate ( -Glu) into GABA via decarboxylation. Compared with other methods, develop bioconversion platform to produce considerable interest for industrial use. Results Thre...

Patients with autoimmune polyendocrine syndrome type I (APS I) have autoantibodies against the enzyme aromatic L-amino acid decarboxylase (AADC) of pancreatic beta-cells. The aim of the present study was to investigate the presence of anti-AADC antibodies in a large cohort of patients with APS I, and in patients with isolated insulin-dependent diabetes mellitus (IDDM). We found autoantibodies a...

There is ample experimental evidence which indicates that 4-aminobutyric acid is an inhibitory neurotransmitter in mammalian brain. Changes in 4-aminobutyric acid concentrations in the central nervous system have therefore prompted speculation regarding its involvement in neurological aberrations. Individuals homozygous for cystathionine /3-synthase deficiency (an autosomal recessive inherited ...

–Dopaminergic axons arising from midbrain nuclei innervate the mammalian and avian telencephalon with heterogeneous regional and laminar distributions. In primate, rodent, and avian species, the neuromodulator dopamine is low or almost absent in most primary sensory areas and is most abundant in the striatal parts of the basal ganglia. Furthermore, dopaminergic fibres are present in most limbic...