This study evaluated the effect of selenium and extracts of Gongronema latifolium on some biochemical parameters in alloxan-induced diabetic rats. Forty male albino rats equally divided into eight experimental groups were used. Two groups served as normal and diabetic control and received placebo treatment. Four diabetic test groups were treated with G. latifolium extract, glibenclamide, combin...

Killer lectin-like receptor NKG2D, which is found on natural killer cells, recognizes MHC class 1-related ligands and also interacts with glycan ligands, heparin-conjugated bovine serum albumin (heparin-BSA) and sialyl Lewis X (sLeX) on multi-antennary N-glycans on transferrin secreted by HepG2 cells (HepTF). Using the glutathione-Stransferase-fused extracellular domain (AA 73-216) of NKG2D (rG...

Introduction Estuarine ecosystems are under high anthropogenic pressure and receive a wide Q7 variety of contaminants, including metals. They can remain trapped in estuarine sediments at concentrations for long periods but eventually they be released to the overlying water become toxic resident benthic biota. As consequence, biomonitoring programs surveying health status estuaries coastal areas...

A strain of house fly was collected from the Third Yumenoshima Island in Japan and selected with the pyrethroid insecticide permethrin. Resistance to permethrin evolved to >18; 400-fold in the selected (YPER) strain, and the mechanisms and genetics of resistance in this strain were examined. Permethrin resistance was decreased by pretreatment with piperonyl butoxide or 2-propynyl 2,3,6-trichlor...

Src Homology III (SHB) domains are small (55-?0 amino acids) receptor domains that are found in many signaling proteins and are involved in intracellular signaling events.t2 For example, the SH3 domain in the adaptor protein GRB-2 facilitates the coupling of growth factor receptors to an essential switch in growth-related signaling pathways-the guanine nucleotide binding protein Ras.3 Another e...

Background: Despite marked improvement in therapy and monitoring of patients with insulindependent (type1) diabetes, diabetic nephropathy remains a serious complication, with subsequent endstage renal disease in about 20% of cases. Objective: To investigate in young patients with type1 diabetes whether urine -Glutathione Stransferase to creatinine ratio (-GST:crea) relates to markers of syste...

The polycyclic aromatic hydrocarbon 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) is related to the industrial byproduct dioxin and is a weak agonist and partial antagonist at the aryl hydrocarbon receptor (AhR). Tamoxifen is used for the treatment and prevention of breast cancer and interferes with the interaction of estrogen with estrogen receptor (ER). The combination of MCDF and tamoxifen low...

In this study, the receptors and signals involved in collagen-induced platelet spreading were examined. It was found that platelet spreading on collagen (presenting a polygon shape with a number of filopodialike projections) was inhibited by the anti–integrin a2 antibody, suggesting the involvement of integrin a2b1 in this process. Studies with a glutathione-Stransferase fusion protein that bin...

Glycine receptors (GlyRs) mediate inhibitory neurotransmission in spinal cord and brain stem. They are clustered at inhibitory postsynapses via a tight interaction of their β subunits (GlyRβ) with the scaffolding protein gephyrin. In an attempt to isolate additional proteins interacting with GlyRβ, we performed pull-down experiments with rat brain extracts using a glutathione Stransferase fusio...