Monoglycerides and unsaturated fatty acids, naturally present in trace amounts in the stratum corneum (top layer of skin) lipid matrix, are commonly used in pharmaceutical, cosmetic and health care formulations. However, a detailed molecular understanding of how the oil additives get incorporated into the skin lipids from topical application and, once incorporated, how they affect the propertie...

THE PROCEDURE of Stoffel, Chu, and Ahrens (1) for preparing and separating the methyl esters of fatty acids and the dimethylacetals (DMA) when applied to brain lipid extracts proved adequate for the nonoxygenated fatty acids and DMA. Some of the cholesterol in the extract, however, was converted to derivatives, one of which, A3kholestadiene (2), sublimed along with the methyl esters and the DMA...

The objective of the current study was to formulate solid lipid nanoparticles of oxybenzone to enhance its sunscreening efficacy while reducing its side effects. Solid lipid nanoparticles (SLNs) of oxybenzone were prepared by the solvent diffusion method. A complete 2(4) factorial design was used to optimize preparations. The study design involves the investigation of four independent variables...

Objective: This research aims to optimize the solid lipid nanoparticles by using full factorial design improve delivery of rivastigmine tartrate (RT), which is used for treatment Alzheimer’s disease (AD). Solid (SLNs) are attracting importance drug developers due their performance. The outcome this will lead improvements in release and solubility RT better therapeutic effect. Methods: Four diff...

Lansoprazole fast-disintegrating tablet (LFDT) is a new patient-friendly formulation of lansoprazole. Since lansoprazole is an antiulcer agent and is unstable under acidic conditions, we have developed LFDT as an orally disintegrating tablet containing enteric-coated microgranules. The effect of compression on dissolution behavior was investigated, as compression affected cleavage and crushing ...

Gastric acidity is the main factor affecting viability of probiotics in the gastrointestinal tract (GIT). This study investigated the survival in simulated gastrointestinal fluids of Bifidobacterium longum Bb-46 encapsulated in interpolymer complexes formed in supercritical carbon dioxide (scCO(2)). Bacteria were exposed sequentially to simulated gastric fluid (SGF, pH 2) for 2 h and simulated ...

Nowdays, the design of the optimalniosomal formulation may ensure the best performance in terms of physico-chemical properties and drug skin permeation. Our study want to propose the loading of Tetracycline or Tetracycline hydrocholoride drugs as strategy to modulate niosomes properties, with particular emphasis on encapsulation and percutaneous permeation behavior. Niosomes were prepared from ...

Starch is a biodegradable polymeric carbohydrate that can easily form films and coatings readily be obtained from some food industry by-products wastes, which may contribute to the circular bioeconomy. In this work, we studied potential of two edible coating emulsions based on pregelatinized potato starch (PPS) glyceryl monostearate (GMS) alone (F6 F10) or formulated with additive sodium benzoa...

OBJECTIVE In the light of the reported inconsistent anti-ischaemic and antianginal effects of transdermal glyceryl trinitrate, its efficacy and influence on the effects of intracoronary glyceryl trinitrate were examined during coronary angioplasty, which provides a model of controlled, reversible ischaemia. DESIGN Double blind, randomised study of the effect of transdermal and intracoronary g...