*Correspondence: R. M. Mainardes. Departamento de Farmácia. Laboratório de Nanotecnologia Farmacêutica. Universidade Estadual do Centro-Oeste – UNICENTRO. Rua Simeão Camargo Varela de Sá, 03 85040-080 Guarapuava – PR, Brasil. E-mail: [email protected] A stability-indicating HPLC-PDA method for the determination of ferulic acid in chitosan-coated poly(lactide-co-glycolide) nanoparticles

membrane permeability and p-glycoprotein (p-gp) efflux system are regulating factors in the drug brain penetration. recently, some drug delivery systems have been developed to overcome these limitations. in this study, metoclopramid has been encapsulated in plga nanoparticles using the emulsification/solvent evaporation technique for in vitro evaluation of the effect of plga nanoparticles on bb...

microspheres formulated from poly (d,l-lactic-co-glycolide) (plga), a biodegradable polymer, have been extensively evaluated as a drug delivery system. in this study, the preparation, characterization and drug release properties of the plga microspheres were evaluated. simvastatin (sim)-loaded plga microspheres were prepared by oil-in-water emulsion/solvent evaporation method. the microspheres ...

docetaxel (dtx) is one of the most widely used drugs in oncology due to its high efficacy against several cancers. though, its routine clinical administration, formulated in tween 80, causes serious side effects. polylactide-co-glycolide (plga), biodegradable polyester synthesized and approved for human use, is employed to overcome this problem. in this investigation, we compare the cytotoxic m...