Transient regional increases in brain activity associated with task performance result in elevated glucose metabolism greater than the corresponding increase in oxygen consumption (aerobic glycolysis). Aerobic glycolysis is also present in the resting adult brain but neither its regional pattern nor its mission is known. We studied the distribution of aerobic glycolysis in the resting human bra...

Prostaglandins E1 and E2 increased the sensitivity of glycolysis to insulin in the isolated stripped soleus muscle of the rat, but prostaglandin F2 alpha had no effect. Indomethacin, which inhibits prostaglandin formation, markedly decreased the sensitivity of glycolysis to insulin. These findings suggest that prostaglandins of the E series increase the sensitivity of muscle glycolysis to insul...

Tumor cells have higher rates of glucose uptake and aerobic glycolysis to meet energy demands for proliferation and metastasis. The characteristics of increased glucose uptake, accompanied with aerobic glycolysis, has been exploited for the diagnosis of cancers. Although much progress has been made, the mechanisms regulating tumor aerobic glycolysis and energy production are still not fully und...

objective(s): this study aimed to evaluate the role of pretreatment suvmax and volumetric fdg positron emission tomography (pet) parameters in the differentiation between benign and malignant mediastinal tumors. in addition, we investigated whether pretreatment suvmax and volumetric fdg-pet parameters could distinguish thymomas from thymic carcinomas, and low-risk from high-risk thymomas.method...

Ureaplasma, a member of mycoplasmas, has a unique ATP synthesis system, which is coupled to the urea hydrolysis. Urease catalyzes the hydrolysis of urea into carbon dioxide and ammonia. Phylogenetic analyses of the urease genes indicated that Ureaplasma urease genes were not gained by recent horizontal transfer and have a unique evolutionary process. Ureaplasma unique ATP synthesis system leade...

Abstract CTLA4 blockade improved T-cell infiltration and function in glycolysis-low tumors.

background chronic hypoxia causes apoptosis of cardiac myocytes, however, energy production by anaerobic glycolysis protects myocardium against hypoxia injuries. aldolase a is a well-characterised key enzyme of the glycolysis pathway. ghrelin, a 28-amino-acid peptide, synthesizes in the stomach and has protective roles in cardiovascular systems and also affects metabolic pathways. objectives th...

CANCER IS A METABOLIC DISEASE AND THE SOLUTION OF TWO METABOLIC EQUATIONS: to produce energy with limited resources and to fulfill the biosynthetic needs of proliferating cells. Both equations are solved when glycolysis is uncoupled from oxidative phosphorylation in the tricarboxylic acid cycle, a process known as the glycolytic switch. This review addresses in a comprehensive manner the main m...

Certain of the metabolic events associated with anaerobic sodium transport by the isolated bladder of the fresh water turtle have been investigated. The data suggest that energy for this transport arises from glycolysis and that endogenous glycogen was the major and perhaps the sole source of substrate. The rate of anaerobic glycolysis, as determined by lactate formation, correlates well with t...