Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterized by diminished response of the target tissue to thyroid hormone caused, in the majority of cases, by mutation of the thyroid hormone receptor beta (THRβ) gene. Despite elevated serum levels of free thyroid hormones and thyroid stimulating hormone (TSH), the paucity of symptoms and signs of thyroid dysfunction suggest ...

Background. Due to the rapid increase in prevalence of childhood obesity Europe recent years, various initiatives and actions have been launched response this alarming tendency. Over last decade, question interaction between thyroid pathology has most controversial. The study was aimed assess state supply overweight children. Materials methods. Out 936 people, 160 people aged 7 18 years with (O...

Thyroid hormone resistance (THR) is a dominantly inherited syndrome characterized by reduced sensitivity to thyroid hormones. It is usually caused by mutations in the thyroid hormone receptor beta (THRB) gene. In the present report, we describe the clinical and laboratory characteristics and genetic analysis of patients with a novel THRB gene mutation. The index patient had been misdiagnosed as...

Sudden death due to thyroid disorders is a rare occurrence in forensic practice. Marked changes of thyroid plasma hormones in short periods of time are known to be life threatening, but they are usually identifiable in patients with known thyroid disorders, and therefore do not comply with the definition of sudden death. In order to properly identify published sudden thyroid death cases we perf...

SUMMARY Different degrees of neurological and psychological problems are observed in endemic goiter inhabitants. To determine the effect of iodine deficiency on IQ, we checked the IQ and size of the thyroid of 194 students of an endemic goiter area and compared with that of 224 students of a non-endemic goiter area in Kohkiloyeh & Boyer Ahmad province. The average IQ of students in endemic goi...

Over the past two decades a plethora of publications and clinical practice data have established that subclinical thyroid dysfunction is a common condition occurring much more frequently than the overt expression of thyroid disease. Subclinical hypothyroidism is considered to be the most common of these entities. However, far more common and relatively less studied is exogenous sublinical hyper...

Hashimoto thyroiditis (HT), now considered the most common autoimmune disease, was described over a century ago as a pronounced lymphoid goiter affecting predominantly women. In addition to this classic form, several other clinico-pathologic entities are now included under the term HT: fibrous variant, IgG4-related variant, juvenile form, Hashitoxicosis, and painless thyroiditis (sporadic or po...

Fetal goiter is an uncommon, serious problem during pregnancy. Careful routine antenatal ultrasound screening can find out an intrauterine fetal goiter. Fetal goiter has an incidence of 1:40000 live births (1). 80% of cases are caused by dysgenesis of the thyroid gland. The rest 5% and 15% are due to hypothalamohypophyseal abnormalities and dyshormonogenesis, respectively. 8% of cases are due t...

Hashimoto's thyroiditis (HT) is part of the spectrum of autoimmune thyroid diseases. Clinical manifestations of HT are variable and commonly include diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. Uncommonly, HT causes acute destruction of thyroid tissue and release of stored thyroid hormones, causing transient thyrotoxicosis (hashitoxicosis...

Results The RTH children had goiter, irritability, aggressiveness, and hyperhidrosis. The TFTs showed high levels of circulating free thyroid hormones (FT4 and FT3) and normal or high thyroid-stimulating hormone (TSH) concentrations. All of these patients used bromocriptine, and then clinical presentations got improved obviously without obvious advert effect. From these three patients and their...