Renovascular hypertension has its experimental counterpart in the two-kidney, one clip model (Goldblatt hypertension). From the study of this model, a general pathophysiological scheme has evolved suggesting that temporal stages in the development and maintenance of hypertension are regulated by complicated hormonal and neural interrelations. The central roles played by the renin-angiotensin sy...

The pathogenesis of renal hypertension remains a mystery. Renal disease can be severe enough to produce terminal uremia without producing hypertension. On the other hand, hypertension can be induced by partial constriction of the renal artery, and the kidney in question may retain good excretory function. The excretory activities of the kidney seem not to be directly related to its hypertensive...

The changes in ventricular isomyosin composition and Ca2+-activated ATPase activity occurring with regression of both hypertension and cardiac hypertrophy were investigated by using polyacrylamide gel electrophoresis under nondenaturing conditions, heavy chain peptide mapping, and an enzymatic assay. Eight control male Wistar rats and 14 two-kidney, one clip (Goldblatt II) hypertensive rats wer...

Endothelial regeneration after a narrow, superficial aortic injury was studied in rats with chronic Goldblatt hypertension, genetic hypercholesterolemia, or a combination of hypertension and genetic hypercholesterolemia. In all groups, endothelial continuity was restored within 24 to 36 hours by a combination of endothelial migration and proliferation. A line of increased endothelial density co...

The aim of this study was to assess the antihypertensive activity of fasidotril, a dual inhibitor of neprilysin (NEP) and angiotensin I-converting enzyme (ACE), in various models of hypertension in rats (spontaneously hypertensive rats [SHR]; renovascular Goldblatt 2-kidney, 1-clip rats; and deoxycorticosterone acetate [DOCA]-salt hypertensive rats) and in patients with mild-to-moderate essenti...

A persistently raised blood pressure is uncommon in children. Essential hypertension is rare, only a few cases having been recorded (Court, 1941). Endocrine causes, such as the hyperadrenalism of phaeochromocytomata (Snyder and Vick, 1947) are also uncommon. Elevation of the systolic pressure occurs in diseases of the heart and great vessels, being most notable in coarctation of the aorta and i...

Changes in potassium (K) concentration in erythrocytes (RBC) were investigated during the early developing stage (1 and 2 weeks after) and the chronic established stage (12 to 16 weeks after the renal artery constriction) in two-kidney (group 2H) and one-kidney Goldblatt hypertension (group 1H) of the rabbit. In both group 2H and group 1H, blood pressure was already elevated significantly durin...