BACKGROUND Various purine-rich foods and high protein intake have long been thought to be risk factors for gout. Similarly, the possibility that the consumption of dairy products has a role in protecting against gout has been raised by metabolic studies. We prospectively investigated the association of these dietary factors with new cases of gout. METHODS Over a 12-year period, we prospective...

It has been hypothesized that the association between hypertension and gout is bidirectional, however, few studies have examined this in a prospective cohort. We analyzed data from the Singapore Chinese Health Study (SCHS) follow-up I (1999-2004) and II (2006-2010) interviews, when both physician-diagnosed hypertension and gout were self-reported. We included participants with data for both fol...

BACKGROUND For patients to effectively manage gout, they need to be aware of the impact of diet, alcohol use, and medications on their condition. We sought to examine patients' knowledge and beliefs concerning gout and its treatment in order to identify barriers to optimal patient self-management. METHODS We identified patients (≥18 years of age) cared for in the setting of a multispecialty g...

BACKGROUND Gout is a common cause of inflammatory arthritis in the United States, and its prevalence has increased in recent decades, especially among older adults. Older adults with gout are of particular interest because they tend to experience higher rates of tophi, an advanced stage of gout, than do younger patients. OBJECTIVE For older adults with gout to (1) assess health care utilizati...

OBJECTIVE A genome-wide association study (GWAS) of gout and its subtypes was performed to identify novel gout loci, including those that are subtype-specific. METHODS Putative causal association signals from a GWAS of 945 clinically defined gout cases and 1213 controls from Japanese males were replicated with 1396 cases and 1268 controls using a custom chip of 1961 single nucleotide polymorp...

Gout is a common inflammatory arthritis triggered by the presence of monosodium urate (MSU) crystals in joints and connective tissues. Current evidence suggests that heredity contributes to gout progression. It is increasingly assumed that gout occurs when serum uric acid (SUA) levels exceed the physiological saturation threshold for uric acid. This study aims to investigate whether variations ...

INTRODUCTION The aim of this study was to assess the accuracy of Veterans Affairs (VA) databases for gout-related health care utilization. METHODS This retrospective study utilized VA administrative and clinical databases. A random sample of gout patients with visits (outpatient, inpatient or emergent/urgent care) with or without the diagnosis of gout (International Classification of Diseases...

Gout, a metabolic disorder, is commonly accepted as a peripheral joint disease of the appendicular skeleton by the deposition of monosodium urate crystals. Gouty involvement of the spinal column is rare. In this paper, we report a case of spinal gout with spondylolisthesis, meanwhile, we review the clinical, radiological features, diagnosis and treatment of spinal gout in literature. The patien...

Gout is the most common inflammatory arthritis in the United States, with more than three million sufferers. Management of gout has changed relatively little in the past 50 years, despite the fact that many gout patients have contraindications to one or more currently available gout therapies. However, recent insights into gout pathophysiology suggest that time is ripe for a change. This articl...

Urate is a frequently measured blood test in people with gout and those at risk of gout. Although gout is potentially curable with long-term urate lowering therapy, confusion about the details of urate measurement has contributed to suboptimal care. In this article, we provide recommendations regarding urate testing in gout, focusing on the use of this test in clinical practice.