BACKGROUND & AIMS Education of patients with chronic hepatitis C has been proposed to increase response to therapy with peginterferon and ribavirin. We performed a prospective study to determine the effects of systematic consultation by a nurse on patient adherence and the efficacy of therapy. METHODS We analyzed data from 244 patients who received either systematic consultation after each me...

In machine learning, multiclass or multi-label classification is the special case within statistical classification of assigning one of several class labels to an input object. The multiclass problem is more complex than binary classification and less researched problem. In biology promoter is the DNA region where the transcription initiation takes place. Reliable recognition of promoter region...

We have previously evaluated the beneficial effect of the group reminiscence approach (GRA) in patients with vascular dementia (VaD) in respect of cognitive and observed behavioral parameters [1] . Sixty patients who had been diagnosed with VaD were randomly assigned to three arms: a GRA arm, a social contact (SC) arm, and a control arm. A 1-hour session of GRA and SC was held once a week for 3...

BACKGROUND The prevalence of primary hyperaldosteronism (PHA) in the hypertensive population has increased in recent years. Glucocorticoid-remediable aldosteronism (GRA) is a rare monogenic form of PHA. Here we report a German family with GRA. Since the phenotype of GRA varies widely, we asked whether recommended algorithms for PHA diagnosis distinguish GRA from other forms of PHA. METHODS Pl...

18β-Glycyrrhetinic acid (GRA), a major component of Glycyrrhiza glabra, is widely used therapeutically in clinic. In this study, the effect of GRA on Helicobacter pylori- (H. pylori-) infected gastritis was investigated in Mongolian gerbils in vivo. The gerbils were randomly divided into groups: uninfected; H. pylori-infected; H. pylori + antibiotics (clarithromycin, amoxicillin, and esomeprazo...

The genes for polyketide synthases (PKSs), enzymes that assemble the carbon backbones of many secondary metabolites, often cluster with other secondary pathway genes. We describe here the first lichen PKS cluster likely to be implicated in the biosynthesis of a depside and a depsidone, compounds in a class almost exclusively produced by lichen fungi (mycobionts). With degenerate PCR with primer...

Introduction: Although some CR chondrites are recognized to be among the most pristine meteorites [1], other members of this group are heavily hydrated [e.g. 2]. However, no evidence of thermal metamorphism has been documented for this group. Antarctic fall GRA 06100, initially classified as a CR2 chondrite have not been previously studied. We use optical microscopy, SEM, and focused beam EPMA ...