Results of a previous study suggested that recipient mismatching for the minor histocompatibility antigen HA-1 is associated with acute graft-versus-host disease (GVHD) after allogeneic marrow transplantation. In that study, most patients received either cyclosporine or methotrexate for GVHD prophylaxis, and a cytotoxic T-cell clone was used to test for HA-1 disparity. To facilitate large-scale...

The success of allogeneic hematopoietic stem cell transplantation (HSCT) from matched unrelated donors (UDs) for beta-thalassemia may be hampered by the occurrence of graft rejection. Here, we show that the rate of this complication can be reduced by selecting 5-loci HLA-matched donors without nonpermissive mismatches at HLA-DPB1, defined according to an algorithm previously described and based...

Donor leukocyte infusion (DLI) can induce graft-versus-leukemia (GvL) reactions in patients with chronic myeloid leukemia (CML) relapsing after allogeneic bone marrow transplantation (BMT), but the mechanisms of the antileukemic effect of DLI are unknown, and the procedure is complicated by graft-versus-host disease (GvHD) and graft failure. Here, we adapted a murine retroviral BMT model of Phi...

results urban patients were more likely to receive supplementary information and being strongly encouraged by their nephrologists to seek transplant. all participants acknowledged “independence” as the main advantage of transplantation. increased freedom to travel and improved life expectancy were mentioned only among the urban groups. the main themes in all groups regarding perceived barriers ...

background : one of the major health policy issues, in the both developed and developing countries, is the equality in the distribution of health resources. the aim of this study was to investigate the disparity in the distribution of health physical resources across the provinces of iran in 2001 and 2011. methods : this was a cross-sectional retrospective study which investigated inequality in...

Hepatitis C virus (HCV) infection remains the most common cause of hepatic failure requiring orthotopic liver transplantation, and the disparity between the number of patients in need of liver replacement and the number of organs available continues to grow. Unfortunately, without viral eradication before transplantation, HCV recurrence is universal and is associated with poor graft and patient...

the reduction in regional differences to stop the movement and displacement of human forces and capital in the direction of preparing the ground for development is very effective. development means boosting human potentials for the improved utilization of his environment. rational utilization depends on economical, social and cultural particulars. therefore any kind of condition that is effecti...

purpose: to determine stereopsis with local (titmus) and global (tno) tests in symptomatic and asymptomatic subjects according to induced disparity (crossed or uncrossed). methods: in this cross sectional study, 80 students of zahedan university of medical sciences who fulfilled the inclusion criteria were randomly selected. at first, refractive error was determined by retinoscopy and then base...

Kidney transplantation is the treatment of choice for end-stage renal disease. It offers better quality of life and minimizes the mortality risk for patients when compared with maintenance dialysis therapy (Chailimpamontree W, et al., 2009). Little data are available concerning the impact of the post-transplantation glomerulonephritis (GN) on graft outcome (Gaston R, 2006). The post-transplant ...