An effective networked knowledge delivery platform is one of the Holy Grails of Web computing. Knowledge delivery approaches range from the heavy and narrow to the light and broad. This paper explores a lightweight and flexible dialog framework based on the ALICE system, and evaluates its performance in chat and knowledge delivery using both a conversational setting and a specific telecommunica...

Introdução: A segurança de ambientes institucionais, que contenham bens valor, muitas vezes é feita por sistemas hardware e software proprietários custo alto. Visando amenizar esse problema, o presente artigo propõe uma solução inicial baseada em desenvolvimento utilização gratuitos, sua maioria código aberto, para no futuro possa ser usada proteger esses ambientes. Temos como objetivo propor u...

Logic programming provides a high-level view of programming, giving implementers a vast latitude into what techniques to explore to achieve the best performance for logic programs. Towards obtaining maximum performance, one of the holy grails of logic programming has been to design computational models that could be executed efficiently and that would allow both for a reduction of the search sp...

Due to their sensitivity and speed, mass-spectrometry based analytical technologies are widely used to in metabolomics to characterize biological phenomena. To address issues like metadata organization, quality assessment, data processing, data storage, and, finally, submission to public repositories, bioinformatic pipelines of a non-interactive nature are often employed, complementing the inte...

Creating realistic-looking skin is one of the holy grails of computer graphics and is still an active area of research. The problem is challenging due to the inherent complexity of skin and its variations, not only across individuals but also spatially and temporally among one. Skin appearance and reflectance vary spatially in one individual depending on its location on the human body, but also...

Attention and consciousness. These are perhaps benefited from proper divisions of papers into chapthe holy grails of our scientific quest into the mind. ters with section prefaces. Without this, it can often Whereas the latter is so difficult to even define, the be difficult to find a direct relevance amongst the former is somewhat more comprehensible, if not at different articles. least defina...

Migraine is considered one of the most prevalent neurological disorders but its underlying pathophysiology is poorly understood. Over the past two decades, it became widely accepted that activation of primary afferent nociceptive neurons that innervate the intracranial meninges serves as a key process that mediates the throbbing head pain of migraine. Knowledge about the endogenous factors that...

Background: The prevention of scleral show is truly one of plastic surgery’s Holy Grails. This postoperative problem may be considered subtle, but it represents the most common cause of the “operated” look that we all strive to avoid. Of course, the postoperative fear of a true ectropion is all too common. These concerns, borne out in patient results following the traditional skin-muscle techni...

The majority of healthy individuals exposed to Mycobacterium tuberculosis will not develop disease and identifying what constitutes "protective immunity" is one of the holy grails of M. tuberculosis immunology. It is known that IFN-gamma is essential for protection, but it is also apparent that IFN-gamma levels alone do not explain the immunity/susceptibility dichotomy. The controversy regardin...

Prognostic factors have considerable influence in the management of cancer, and the quest for a thorough understanding of these elements remains one of the holy grails of surgeons and oncologists. In squamous cell carcinoma of the head and neck, the presence or absence of cervical lymph node metastases at presentation has been identified as the single most important independent factor affecting...