background langerhans cell histiocytosis (lch) is a rare disease in which monoclonal migration and proliferation of specific dendritic cells is seen. the disease primarily affects the bones and skin, but there is a possibility that involves other organs or appears as a multi-systemic disease. case report in oral examination of a nine-month girl, two deep wounds with a yellow membrane with appro...

Granulomatous inflammation in the lung may occur from a variety of causes. Many of these are the result of specific antigens that reach the lung and induce a granulomatous response. A prototype of this schema is pulmonary tuberculosis where the organism serves as the inciting antigen. Treatment of tuberculosis is aimed at killing and clearing the organism. It would be foolhardy and potentially ...

PURPOSE To compare the morphologic features of keratic precipitates (KPs) by confocal microscopy in granulomatous versus nongranulomatous noninfectious uveitis. METHODS KP morphology was determined by confocal scan in patients with noninfectious granulomatous and noninfectious nongranulomatous uveitic cases. RESULTS One hundred and twenty-seven eyes of 90 subjects with noninfectious uveitis...

Enteric granulomatous inflammation can be caused by a number of conditions including Crohn's disease, sarcoidosis, enteric infections, chronic granulomatous disease and also by drug reactions. Granulomas have also been described in microscopic colitis associated with certain medications and autoimmune diseases. The association of granulomatous ileocolitis with coeliac disease is not common. We ...

In patients with malignancy, the common etiologies of granuloma formation are tumor related sarcoid reaction, sarcoidosis, tuberculosis and other granulomatous diseases. Often, the finding of granulomas in malignant patients may obscure the primary malignancy or may mislead towards treatment of infectious and other etiologies. Hence, their proper recognition and necessary follow up is needed to...

BACKGROUND Idiopathic granulomatous mastitis is an uncommon, benign entity with a diagnosis of exclusion. The typical clinical presentation of idiopathic granulomatous mastitis often mimics infection or malignancy. As a result, histopathological confirmation of idiopathic granulomatous mastitis combined with exclusion of infection, malignancy and other causes of granulomatous disease is absolut...

Etiopathogenesis of pulmonary granulomatous lesions can be very varied. Pathologists find pulmonary granulomatous lesions in autopsies frequently. Diagnostics of pulmonary granulomatous lesions is based on anamnesis data, clinical examinations and morphological changes. In some cases, especially in long-term ill patients, morphological finding remains the only way to explain the case. We provid...

BACKGROUND Failure to generate phagocyte-derived superoxide and related reactive oxygen intermediates (ROIs) is the major defect in chronic granulomatous disease, causing recurrent infections and granulomatous complications. Chronic granulomatous disease is caused by missense, nonsense, frameshift, splice, or deletion mutations in the genes for p22(phox), p40(phox), p47(phox), p67(phox) (autoso...