Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight rati...

In the current work, the properties of cement pastes doped with high amounts of ground granulated blast-furnace slag (HVS) were investigated. Portland cement (PC) was substituted with ground granulated blast-furnace slag (donated as slag) at very high amounts of 85%, 90%, 95% and 100%, by weight. PC paste without any content of slag was used as a reference. Some fresh and hardened properties su...

Installing stone columns in the ground is an effective improvement technique to increase the load bearing capacity and reduce the consolidation settlement of the loose or weak cohesive soils. In addition to the increase in the bearing capacity and reduction in the settlement, stone columns can accelerate the dissipation rate of the excess pore water pressure generated by the surcharge, which ex...