Abstract Background Hereditary transthyretin-mediated (hATTR) amyloidosis, also known as ATTRv is a rapidly progressive, multisystem disease. Orthostatic hypotension, due to autonomic neuropathy, common yet hard-to-treat disease manifestation in patients with hATTR amyloidosis. Fatigue, muscle weakness, and deterioration cardiac function further exacerbate orthostatic symptoms. Efficacy of RNAi...

CONTENTS Page Introduction .................................................................................................................. 127 Megascopic structures ...................................................................................................... 128 Hand-specimen petrology .....................................................................................................

The Apollo Structured Vocabulary (Apollo-SV) is a Web Ontology Language 2 (OWL 2) representation of terms related to epidemic simulation. We are developing Apollo-SV by ontological analysis of the information used and created by epidemic simulators and the entities this information is about. A key finding of our analysis is that the input of an epidemic simulator is properly understood as (1) a...

Lunar highland meteorites contain small proportions of mare basalt fragments, which are important for defining lunar basalts in areas not visited by Apollo/Luna. We analyzed seven mare basalt fragments from three highland meteorites, and retrieved the Ti contents of their parent magmas from core pyroxene compositions. The analyzed clasts span the range of VLT and low-Ti, basalts in Apollo & Lun...

Lunar sample 15474,4 is a tiny fragment of olivine-augite vitrophyre that is a mare basalt. Although petrographically distinct from all other Apollo 15 samples, it has been ignored since its first brief description. Our new petrographic and mineral chemical data show that the olivines and pyroxenes are distinct from those in other basalts. The basalt cooled and solidified extremely rapidly; som...

Introduction: Impact melt breccias from Apollo 16 and 17 show subtle but resolvable differences in trace element composition between the two sites, possibly indicating regional heterogeneity in the KREEP component contributing to these breccias. The compositional differences are most apparent in the high-field strength elements (HFSE; e.g., Zr, Hf, Nb, Ta), which are fractionated in KREEP relat...

Figure 1: Location of lunar landing sites and the Apollo passive seismometer network. INTRODUCTION Geophysical observations of the Moon via a global and long-lived network of stations will yield a wealth of knowledge from regions heretofore inaccessible using the Apollo database. Data collected over a period of at least 6 years (covering one lunar tidal cycle) will yield information on the natu...