Previously we have reported an increased renal alpha 1- and beta-adrenergic receptor expression in male spontaneously hypertensive rats that occurred ontogenetically in parallel with blood pressure elevation. However, increased receptor numbers were not accompanied by enhanced stimulation of inositol phosphate and cyclic AMP formation, respectively, indicating relative desensitization. We have ...

Intensifying winter wheat ( Triticum aestivum)–grain sorghum [ Sorghum bicolor (L.) Moench]–fallow (W–GS–FL) crop rotation with annual forages can increase productivity and resource use efficiency. The objective of this research was to quantify the impact increasing intensity by growing in a traditional W–GS–FL on cropping system productivity, water use, precipitation efficiency, net income. st...

Aerodynamic measurements of latent (λE) and sensible heat (H) exchange were made in an intensively managed peat pasture during 2 consecutive years; the fetch was approximately 1.5 km. The surface conductance (gs) was calculated from the Penman-Monteith equation. The analysis focused on 2 successive aspects of gs: gs as a function of environment (primarily vapour pressure deficit [D]) and the en...

The ultimate cause of genome size (GS) evolution in eukaryotes remains a major and unresolved puzzle in evolutionary biology. Large-scale comparative studies have failed to find consistent correlations between GS and organismal properties, resulting in the 'C-value paradox'. Current hypotheses for the evolution of GS are based either on the balance between mutational events and drift or on natu...

OBJECTIVE To more clearly elucidate the association between prostate volume and Gleason score (GS) upgrading. PATIENT AND METHODS We reviewed 451 patients with prostate cancer with a GS of 6 on biopsy, who underwent radical prostatectomy without neoadjuvant treatment. As a preoperative variable, we assessed the independent effect of prostate volume on GS upgrading. To evaluate the association...

Tonya ha s a b i g ma th t e s t t omor r ow and sh e n e ed s t o s t udy t on i gh t . W hi l e a t t h e g r o c e r y s t o r e s h e s e e s a Ginkgo B i l oba ad v e r t i s emen t t ha t c l a ims i t w i l l imp r o v e h e r memo r y. B e c au s e s h e wan t s t o d o w e l l o n h e r t e s t , s h e buy s t h e Ginkgo B i l oba , g o e s h ome , and r e v i ew s t h e s ame ma th sh...

introduction: citation tracking is a bibliometrics method to analyze the scientific impact of journal articles which can be done through scopus (sc), google scholar (gs), or isi web of knowledge (wos). in the current study, we analyzed the citations to 2006-2012 articles of iranian journal of nuclear medicine (ijnm) in the sc and gs. methods: we retrieved the relevant data from sc and gs offici...

PURPOSE GS-9219, a novel prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG), was designed as a cytotoxic agent that preferentially targets lymphoid cells. Our objective was to characterize the antiproliferative activity, pharmacokinetics, pharmacodynamics, and safety of GS-9219. EXPERIMENTAL DESIGN GS-9219 was selected through screening in proliferation assays and t...

To investigate the pharmacokinetics, safety, and tolerability of GS-9851 (formerly PSI-7851), a new nucleotide analog inhibitor of hepatitis C virus (HCV), we conducted a double-blind, parallel, placebo-controlled, randomized, single-ascending-dose study. Healthy subjects received oral doses of 25 to 800 mg GS-9851. Peak concentrations of GS-9851 in plasma were achieved more rapidly than those ...