Recurrence and metastasis are the major factors associated with the poor prognosis of non-small cell lung cancer (NSCLC). It has been shown that multiple chemokines and their receptors are related to the progression and metastasis of NSCLC. The aim of this study was to conduct an investigation into whether CCL21 and its receptor, CCR7, play a role...

18β-Glycyrrhetinic acid (18β-GA) is a bioactive component of licorice. The anti-cancer activity of 18β-GA has been studied in many cancer types, whereas its effects in lung cancer remain largely unknown. We first showed that 18β-GA effectively suppressed cell proliferation and inhibited expression as well as activity of thromboxane synthase (TxAS) in non-small cell lung cancer (NSCLC) cells A54...

Hypoxanthine phosphoribosyltransferase (HPRT, IMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) can be purified 5-to 10,000-fold from extracts of HeLa (human) cells by a three-step procedure consisting of high-speed centrifugation, adsorption to Sepharose-conjugated HPRT antibody, and sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Purified enzyme labeled in vivo with radioact...

BACKGROUND Gefitinib (Iressa, ZD1839) is a selective epidermal growth factor receptor tyrosine kinase inhibitor. E2F-1 is a critical determinant in cell cycle. Growth signals up-regulate telomerase activity. The effects of gefitinib on E2F-1 and telomerase in A549, H23 and A431 cells were examined. MATERIALS AND METHODS Cell proliferation and cell cycle progression were measured by the WST-1 ...

Smoking is responsible for 90% of lung cancer cases. There is currently no clinically available gene test for early detection of lung cancer in smokers, or an effective patient selection strategy for adjuvant chemotherapy in lung cancer treatment. In this study, concurrent coexpression with multiple signaling pathways was modeled among a set of genes associated with smoking and lung cancer surv...

Two (ONO pincer)ruthenium-complex-bound norvalines, Boc-[Ru(pydc)(terpy)]Nva-OMe (1; Boc=tert-butyloxycarbonyl, terpy=terpyridyl, Nva=norvaline) and Boc-[Ru(pydc)(tBu-terpy)]Nva-OMe (5), were successfully synthesized and their molecular structures and absolute configurations were unequivocally determined by single-crystal X-ray diffraction. The robustness of the pincer Ru complexes and norvalin...

For a graph G we denote by dG(u, v) the distance between vertices u and v in G, by dG(u) the degree of vertex u. The Hosoya polynomial of G is H(G) = ∑ {u,v}⊆V (G) x dG (u,v). For any positive numbers m and n, the partial Hosoya polynomials of G are Hm(G) = ∑ {u, v} ⊆ V (G) dG (u) = dG (v) = m xdG (u,v), Hmn(G) = ∑ {u, v} ⊆ V (G) dG (u) = m, dG (v) = n xdG (u,v). It has been shown that H(G1) − ...

We study optimal policy experimentation by a committee. consider dynamic bargaining game in which committee members choose either risky reform or safe alternative each period. When no redistribution is allowed, the unique equilibrium outcome generically inefficient. allowed (even small amounts), there always exists an that supports for any voting rule without veto players. With players, however...

A tri-block nanoparticle (TBN) comprising of an enzymatically cleavable porous gelatin nanocore encapsulated with gefitinib (tyrosine kinase inhibitor (TKI)) and surface functionalized with cetuximab-siRNA conjugate has been synthesized. Targeted delivery of siRNA to undruggable KRAS mutated non-small cell lung cancer cells would sensitize the cells to TKI drugs and offers an efficient therapy ...