Current strategies for the treatment of Alzheimer's disease (AD) involve tackling the formation or clearance of the amyloid-beta peptide (Aβ) and/or hyper-phosphorylated tau, or the support and stabilization of the remaining neuronal networks. However, as we gain a clearer idea of the large number of molecular mechanisms at work in this disease, it is becoming clearer that the treatment of AD s...

In a Perspective accompanying Abad-Franch and colleagues, Lorenz von Seidlein, Alexander Kekulé, and Daniel Strickman discuss the importance of developing effective strategies to minimize mosquito-borne transmission of human diseases.

BACKGROUND Since Pars Abad district had been known as a focus of visceral leishmaniasis (VL) in Ardabil Province but the prevalence of the disease in nomadic tribes has not been determined, thus, this study was conducted. METHODS This descriptive cross-sectional study was conducted on children up to 12yr old of nomadic tribes from Pars Abad County, Ardabil Province, Iran in 2015. For each ind...

In the acute setting, the majority of patients affected by uncomplicated acute type B aortic dissection (ABAD) can be managed with medical therapy. In these patients, inhospital outcome is generally acceptable, with mortality rates of 1-10% (1,2). However, long-term outcomes in this group is less positive, with a mortality rates reported as 2025% within 3 years. Predictors of long-term complica...

Most prominent accounts of autonomy are active accounts, which means they hold that an agent can be autonomous with respect to a given action only if that agent has appropriately sanctioned that action. Active accounts, however, are vulnerable to the regress problem, since it seems that the required sanctioning actions are themselves just actions that must be sanctioned. Passive accounts hope t...

Indonesia merupakan negara dengan jumlah penduduk mayoritas beragama Islam. Hal ini juga membuat pendaftar haji cukup banyak tiap tahun. Calon jamaah yang menunggu untuk berangkat waktu tunggu keberangkatan lama antara 20 tahun sampai 40 tersebut menjadikan calon melaksanakan ibadah pada usia lansia. Usia lansia mengakibatkan fungsi fisiologi organ tubuh mengalami penurunan sehingga mempengaruh...

WORK AGREEMENT BETWEEN MEDAN HAJI HOSPITAL AND TENDER WINNING CONTRACTORS (According To The Regulation Of Governor North Sumatera No 52 2015 Concerning Procurement Goods And Services Regional Public In Medan Haji Hospitals,

We show that there may be a Milliken-Taylor ultrafilter with infinitely many near coherence classes of ultrafilters in its projection to ω, answering a question by López-Abad. We show that k-coloured Milliken-Taylor ultrafilters have at least k + 1 near coherence classes of ultrafilters in its projection to ω. We show that the Mathias forcing with a Milliken-Taylor ultrafilter destroys all Mill...

Alzheimer׳s disease (AD) is one of the most common dementias showing slow progressive cognitive decline. Progression of intracerebral accumulation of beta amyloid (Aβ) peptides by the action of amyloid binding alcohol dehydrogenase (ABAD), a mitochondrial enzyme and β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and the degradation of Acetylcholinesterase (AChE) the main pathologica...

This research was conducted in order to study the effects of iron fertilization on yield and chemical composition of date palm var. 'Piarom', on 54 trees in Haji-Abad research station of Hormozgan Province. Trees were 12 years old and research treatments were consisted of: 1-Control treatment 2- Soil surface application of Fe in two levels 3-Application of Fe as localized placement method (Chal...