Thermal halogenation of a wide range of metal carbides provides a simple route to a class of so called carbide derived carbon (CDC) materials. The porosity of the CDCs, which is mainly in the microporous regime, may be modulated by choice of metal carbide precursor and halogenation temperature. However, although the pore size of CDCs can be fine-tuned by the choice of synthesis process, the max...

The Brønsted-acidic ionic liquid 1-methyl-3-(4-sulfobutyl)imidazolium triflate [BMIM(SO(3)H)][OTf] was demonstrated to act efficiently as solvent and catalyst for the halogenation of activated organic compounds with N-halosuccinimides (NXS) under mild conditions with short reaction times. Methyl aryl ketones were converted into α-halo and α,α-dihaloketones, depending on the quantity of NXS used...

While alkyl halides are valuable intermediates in synthetic organic chemistry, their use as bioactive motifs in drug discovery and medicinal chemistry is rare in comparison. This is likely attributable to the common misconception that these compounds are merely non-specific alkylators in biological systems. A number of chlorinated compounds in the pharmaceutical and food industries, as well as ...

A 2.4-Å-resolution X-ray crystal structure of the carrier-protein-independent halogenase WelO5 in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipated site of the oxo group in a presumptive cis-halo-oxo-iron(IV) (haloferryl) intermediate. Prior study of related halogenases forecasts substrate hydro...

Modulating alkene reactivity from oxygenation to halogenation with an exogenous ligand via O2 electrochemical reductive activation.

Inorganic nitrile halides have been studied theoretically by quantum-chemical approach and experimentally in the reactions of halogenation, nitration nitro halogenation aromatic compounds alkynes. The generation was eventually proved can be carried out using iodine system (alkali metal halides) presence alkali nitrates an acetic acid medium. It has found that reaction give products iodination, ...

Arylhalides are important building blocks in many fine chemicals, pharmaceuticals and agrochemicals, and there has been increasing interest in the development of more "green" halogenation methods based on enzyme catalysis. However, the screening and development of new enzymes for biohalogenation has been hampered by a lack of high-throughput screening methods. Described herein is the developmen...

A series of potential anticonvulsants have been synthesized. There are eight fluorobenzylamides and three chlorobenzylamides of isocyclic or heterocyclic acids. Two not halogenated benzylamides were also synthesized to compare the effect of halogenation. The aim of the research performed was to evaluate whether halogenation of the mother structure is able to improve its anticonvulsant activity....