نتایج جستجو برای: haptoglobin
تعداد نتایج: 2590 فیلتر نتایج به سال:
Haptoglobin (Hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. Hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. As an important consequence, Haptoglobin-Hemoglobin complex (Hp-Hb) shows considerable antiox...
background: haptoglobin (hp) is a plasma α2-sialoglycoprotein that contains alpha and beta chains. it displays in three common phenotypes, hp1-1, hp2-1, and hp2-2. proteins expressed by polymorphic genes have grossly different molecular sizes resulting in different diffusion rates in the brain. haptoglobin expressed by the hp2-2 genotype has lower hemoglobin-binding capacity than hp1-1 or hp2-1...
We have recently demonstrated in multiple independent population-based longitudinal and cross sectional analyses that the haptoglobin 2-2 genotype is associated with an increased risk for diabetic cardiovascular disease. The chief function of haptoglobin (Hp) is to bind to hemoglobin and thereby prevent hemoglobin-induced oxidative tissue damage. This antioxidant function of haptoglobin is medi...
The concentration of haptoglobin in sera of healthy women and patients with non-malignant and malignant ovarian tumours was measured by two methods, i.e. complex formation with haemoglobin and complex formation with concanavalin A. High correlation (r = 0.74) between both the methods was found in the group of healthy women, but correlation coefficients were much lower in the group of non-malign...
Haptoglobin is an acute phase inflammatory marker. Its main function is to bind hemoglobin released from erythrocytes to aid its elimination, and thereby haptoglobin prevents the generation of reactive oxygen species in the blood. Haptoglobin levels have been repeatedly associated with a variety of inflammation-linked infectious and non-infectious diseases, including malaria, tuberculosis, huma...
ABSTRACT: Bone trauma triggers an acute inflammatory response, which can alter the serum concentration of acute-phase proteins (PFA). We aimed to evaluate effectiveness PFA measurement as a laboratory biomarker for inflammation related bone regeneration. A partial ostectomy right radius was performed on 22 young male rabbits. The complete blood count, albumin, ceruloplasmin, haptoglobin, C-reac...
Hemoglobin binding site and its relationship to the serine protease-like active site of haptoglobin.
Haptoglobin forms a stable, irreversible complex with hemoglobin. The H chain of haptoglobin, which is the subunit that binds hemoglobin, shows strong sequence homology with the serine protease family. This raises the question of whether hemoglobin binds to the protease-like active site pocket of H chain as the protease inhibitors do with serine proteases. This question can be tested by binding...
Int J Leg Med 1993;106:53–4. 14. Mastana SS, Fisher P. Haptoglobin subtypes in the East Midlands (United Kingdom). Int J Leg Med 1994;107:52–4. 15. Loftus BJ, Kim U-J, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, et al. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics 1999;60:295–308. 16. Erickson LM, Kim HS, Maeda N. Junctions between ...
OBJECTIVES The goal of this study was to determine if the haptoglobin phenotype was predictive of cardiovascular disease (CVD) in diabetic mellitus (DM). BACKGROUND Cardiovascular disease is the most frequent, severe, and costly complication of type 2 DM. There are clear geographic and ethnic differences in the risk of CVD among diabetic patients that cannot be fully explained by differences ...
These studies describe the detection of a haptoglobin species, its characterization as the HPR gene product, and its association with both pregnancy and neoplasia. Previous work showed that the early recurrence of human breast cancer correlated with immunohistochemical staining with a commercial antiserum ostensibly directed against pregnancy-associated plasma protein A (PAPP-A). Use of this an...
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