the proliferation of hepatocellular carcinoma (hcc) cells is one of the leading causes of liver cancer mortality in humans. the inhibiting effects of matrine on hcc cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. since, apoptosis plays an important role in hcc cell proliferation. we examined the apoptosis-inducing effect of matrine on tu...

contexts hepatocellular carcinoma (hcc) is one of the most common malignant diseases in the world. because less than 20% of patients with hcc are resectable, various types of non-surgical treatment have been developed. evidence acquisition at present, radiofrequency ablation (rfa) is accepted as the standard local treatment for patients with hcc because of its superior local control and overall...

background: hepatocellular carcinoma (hcc) is a primary liver cancer that frequently causes mortalities. transarterial chemoembolization (tace) is a new palliative treatment for advanced stages of hcc. in this study, we have assessed the results of tace on a group of iranian patients with advanced hcc treated at imam khomeini general hospital. materials and methods: this was a case series, coho...

Sonazoid, a second-generation ultrasound contrast agent, was introduced for the diagnosis of hepatic nodules. To clarify issues with Sonazoid contrast-enhanced ultrasonography hepatocellular carcinoma (HCC), Korean Society Radiology and Abdominal collaborated on guidelines. The guidelines are de novo, evidence-based, selected using an electronic voting system consensus. These include imaging pr...

background: recently, botulinum neurotoxin (bont)-derived recombinant proteins have been suggested as potential botulism vaccines. here, with concentrating on bont type e (bont/e), we studied two of these binding domain-based recombinant proteins: a multivalent chimer protein, which is composed of bont serotypes a, b and e binding subdomains, and a monovalent recombinant protein, which contains...

conclusions verapamil and rifampin were found specific and effective against p-gp expression in hcc. in conclusion, treatment efficacy of most anticancer drugs is increased in combination with verapamil and rifampin against most advanced hcc. objectives the aim of this study was to elucidate the effect of potent carcinogen nitrosamine with and without verapamil and rifampin drugs on p-gp expres...

conclusions scc, lgdn, and hgdn are common associated findings and precursors of hcc in livers infected with hepatitis b. a strict follow-up and a precise and thorough sampling of livers with scc and any abnormal dysplastic nodules (dns), especially those larger than 1 cm, are highly recommended because these dns are highly associated with malignancy. results among all explanted cirrhotic liver...

materials and methods the expression of gp73 was investigated in 88 cancerous and self-control non-cancerous tissues using tissue microarrays with immunohisto- chemistry and was confirmed by western blotting. circulating gp73 levels were detected in the sera of 281 patients with liver diseases using enzyme-linked immunosorbent assay. results the levels of circulating gp73 expression in the hcc ...

conclusions pivka-ii was as efficient as afp when used as a single marker for hcc screening and the combination of two biomarkers gave a better performance. results the sensitivity and specificity of pivka-ii were 74.6% and 67.8% at a cutoff of 40 mau/ml and 64.2% and 89.7% at a cutoff of 200 mau/ml. the sensitivity and specificity of afp were 76.7% and 65.0% at a cutoff of 20 ng/ml and 60.4% a...

conclusions this meta-analysis indicated that the tnf-α-308 g/a polymorphism is significantly associated with increased susceptibility to hcc. however, to confirm this finding, more studies are needed on tnf-α-308 g/a polymorphisms associated with hcc. context hepatocellular carcinoma (hcc) is a common disorder throughout the world that can develop due to various factors, including genetics. tu...