This study was performed to clarify the effects of lidiocaine Hcl, ketamine Hcl and their combination injected into the sacrococcygeal space for posterior epidural analgesia in buffaloes. Five adult buffaloes were randomly received 3 treatments with 2 week interval. The treatments were 7.5 ml of lidiocaine Hcl 2% (Group I), 7.5 ml of ketamine Hcl 2% (Group II) and 7.5 ml combination of lidiocai...

Dear Editor, Differentiation of classic hairy cell leukemia (HCL-c) from HCLvariant (HCL-v) or splenic marginal zone lymphoma (SMZL) is important owing to their different treatment strategies and prognostic implications. Recently, testing for BRAF V600E mutations was suggested as an important diagnostic option for HCL-considering that it was exclusively detected in almost all cases [1]. The BRA...

A functional B-cell receptor (BCR) is critical for survival of normal B-cells, but whether it plays a comparable role in B-cell malignancy is as yet not fully delineated. Typical Hairy Cell Leukemia (HCL) is a rare B-cell tumor, and unique in expressing multiple surface immunoglobulin (sIg) isotypes on individual tumor cells (mult-HCL), to raise questions as to their functional relevance. Typic...

While cimetidine (CIM) is strikingly effective in inhibiting gastric acid secretion, its effect on the defensive mechanisms of the gastric mucosa has been controversial. The aims of the present study were to test if administration of CIM at an antisecretory dose is protective against acid-induced injury and to assess its effect on adaptive cytoprotection induced by non-necrotizing concentration...

BACKGROUND Case reports suggest that hairy cell leukemia (HCL) may be associated with autoimmune conditions, however no systematic investigations in this area have been undertaken. METHODS Using the United States Surveillance, Epidemiology, and End Results Medicare linked database, we conducted an exploratory study comparing autoimmune conditions in 418 HCL cases (aged ≥65 years) and 160,086 ...

We describe the clinical and laboratory features of 17 adult patients with a variant form of hairy cell leukemia (HCL-V) studied over the last 7 years. The main findings were: splenomegaly, moderate anemia, thrombocytopenia, and a raised white blood cell count (median 116 x 10(9)/L; range 15 to 482). The circulating lymphoid cells had abundant villous cytoplasm and a round, occasionally bilobed...

Although increased cholesterol synthesis is a feature of many types of human leukemic cells, cells from patients with chronic lymphocytic leukemia have a low cholesterol content and display normal rates of cholesterol synthesis when compared with normal human peripheral blood mononuclear cells (PBMNC). In contrast, Ieukemic cells from patients with hairy cell leukemia (HCL). another chronic B-c...

Two simple spectrophotometric methods have been developed for simultaneous estimation of drotaverine hydrochloride and aceclofenac from tablet dosage form. Method I is a simultaneous equation method (Vierodt's method), wavelengths selected are 306.5 and 276 nm. Method II is the absorbance ratio method (Q-Analysis), which employs 298.5 nm as λ(1) and 276 nm as λ(2) (λmax of AF) for formation of ...