Introduction The activation of natural killer cells (NK) by their KIR (killer cell immunoglobulin-like receptor) is a potent defense system tumor cells. In this thesis we want to investigate the profile 16 inhibiting and activating KIRs in bloodserum patients with head neck squamous-cell carcinoma (HNSCC). Furthermore, calculate correlation between KIR-status overall survival (OS) HNSCC-patients.

PURPOSE Wild-type sequence (wt) p53 peptides are attractive candidates for broadly applicable cancer vaccines, currently considered primarily for patients whose tumors overexpress p53. Circumstances exist, however, where increased p53 degradation may result in appreciable presentation of p53-derived peptides, despite low p53 expression. Squamous cell carcinoma of the head and neck is associated...

The incidence of skin cancers is low in India when compared to the western world. Malignant transformation discoid lupus erythematosus (DLE) a rare entity. Most common site head and neck. Our case reported disseminated DLE with malignant squamous cell carcinoma (SCC) lesion over arm axillary node involvement. We proceeded wide local excision dissection.

Introduction The receptor tyrosine kinase Axl is described as a driver for migration and metastasis well resistance against molecular targeting agents radio- chemotherapy (RCT) in various tumor entities including head neck squamous cell carcinoma (HNSCC). For the latter, clinical data describing impact of its ligand Gas6 on patient outcome are sparse.

CT: computed tomography HNCSCC: head and neck cutaneous squamous cell carcinoma IMRT: intensity-modulated radiation therapy MMS: Mohs micrographic surgery PNI: perineural invasion RT: radiation therapy SCC: squamous cell carcinoma INTRODUCTION Head and neck cutaneous squamous cell carcinoma (HNCSCC) is a growing problem in the immunosuppressed population, and the behavior of these cancers can b...

An impressive variety of regulatory processes including cell adhesion and migration, proliferation, apoptosis and differentiation folding and routing of glycoproteins have been found to be mediated by specific lectin-carbohydrate interactions. This article summarizes the data on glycobiological aspects of differentiation of squamous epithelia in the head and neck region under physiological cond...

CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baicalein did not enhance apoptosis and upregulated CD44 in head and neck squamous c...

Although much has been characterized about squamous cell carcinoma of the lower female reproductive tract, there is limited knowledge and experience with cases demonstrating squamous cell carcinoma with sarcomatoid features. Sarcomatoid squamous cell carcinoma (SSCC) is mainly found in the upper aerodigestive tract with the larynx being the most common site in the head and neck region. (Otay et...