ESAT-6 (for 6-kDa early secreted antigenic target) is a secreted antigen found almost exclusively in organisms of the Mycobacterium tuberculosis complex. We compared in vitro gamma interferon (IFN-gamma) responses by peripheral blood mononuclear cells to this antigen in patients with pulmonary disease due to either Mycobacterium avium complex (MAC) or Mycobacterium tuberculosis with those in he...

Background and aim: Geographic tongue is a recurrent disorder with several associated etiologies. It is believed to be a common occurrence in the patients suffering from recurrent, acute inflammatory diseases. The purpose of this study was to compare the prevalence of geographic tongue between asthmatic patients and healthy subjects. Materials and Methods: This descriptive-analytic study was...

The most common cause of death in patients with Duchenne muscular dystrophy (DMD) is cardiomyopathy. Our aim was to investigate the relationship between Tpeak–Tend (Tp-e) interval and premature ventricular contraction (PVC) burden therefore early arrhythmic risk cardiac involvement DMD patients. Twenty-five followed by pediatric cardiology were included study. Those a frequency <1% PVC 24 h ...

Background: The significance of cTfh cells and their subsets in atherosclerosis is not well understood. We measured the frequency of cTfh subsets in patients with different degrees of stenosis using flow-cytometry. Methods: Participants included high (≥50%; n = 12) and low (<50%; n = 12) stenosis groups, as well as healthy controls (n = 6). Results: The frequency of CCR7loPD-1hiefficient-cTfh w...

Background: Type 1 diabetes mellitus (T1DM) is a chronic, immune-mediated disease characterized by the destruction of insulin-producing β cells in pancreas. This study investigated influence single nucleotide polymorphisms (SNP) tumor necrosis factor (TNF-α) –308 G/A (rs1800629,) on T1DM patients. Method: The was included 75 patients and 25 healthy subjects. SNP–308 TNF-α gene detected using po...

BACKGROUND The major clinical feature in chronic pancreatitis is pain, but the genetic basis of pancreatic pain in chronic pancreatitis is poorly understood. The transient receptor potential vanilloid receptor 1 (TRPV1) gene has been associated with pain perception, and genetic variations in TRPV1 may modify the presence and phenotype of chronic pancreatitis. The aim of our study was to investi...

PURPOSE Recent data indicate that cDNA microarray gene expression profile of blood cells can reflect disease states and thus have diagnostic value. We tested the hypothesis that blood cell gene expression can differentiate between bladder cancer and other genitourinary cancers as well as between bladder cancer and healthy controls. EXPERIMENTAL DESIGN We used Affymetrix U133 Plus 2.0 GeneChip...

Abstract Introduction Accumulating evidence implicates sleep and circadian rhythm disruption in substance use disorders, including opioid disorder (OUD). Blunted amplitude daily rhythms of circadian-relevant variables (e.g., activity, light) may be a marker psychopathology, as depressed adults demonstrate smaller activity compared with healthy controls. The present study the light amplitudes OU...