OBJECTIVES To determine if the curvilinear relationship between age and voluntary association memberships is due to compositional differences between age groups. METHODS Data are drawn from 12 nationally representative surveys covering the period 1974-1994 and including items on membership in 16 types of associations. Age is categorized into 14 groups ranging from 18-24 through 85+. Patterns ...

We find that a process of voluntary association where individuals express a preference about whom they want to be associated with can create strong incentives to increase efficiency and contributions in provision of a public good. This process of endogenous group formation perfectly sorted contributions by the order of group formation. Comparison of middle and last period behaviour suggests tha...

Background: Eltrombopag is an orally bioavailable small molecule agonist of thrombopoietin receptor (TPO-R) that has been recently approved in the USA for treatment of chronic idiopathic (immune) thrombocytopenic purpura (ITP). The population pharmacokinetics of eltrombopag in healthy volunteers and patients with ITP has been previously described [1]. The model identified health status (healthy...

BACKGROUND Prospective cohort studies recruit relatively healthy population samples, resulting in lower morbidity and mortality rates than in the source population. This is known as the healthy volunteer effect. The aim of this study was to define the magnitude and the development over time of the healthy volunteer effect in the EPIC-NL cohort. METHODS We studied mortality rates in the EPIC-N...