Fluorine-18-2-fluoro-2-deoxy-D-glucose (18F-FDG) injection was prepared by a modification of a method originally developed by Hamacher et al. The dosage form is the injectable solution (2 ml) containing 185 MBq of 18F-FDG at a calibration time. Preclinical studies of the agent were performed. Its radiochemical purity is more than 95% and expiration time is 4 hours after the calibration time at ...

A brief overview is provided of the history of the development of internal dose methods for use in nuclear medicine. Basic methods of internal dosimetry and the systems that have been developed for use in nuclear medicine are described. The development of the MIRD system and the International Radiopharmaceutical Dosimetry Symposium series is outlined. The evolution of models and tools for calcu...

Introduction: In patients with thyroid carcinoma, radiation absorbed doses of the thyroid and surrounding tissues is important to weigh risk and benefit considerations. In nuclear medicine, the accuracy of absorbed dose of internally distributed radionuclides is estimated by different methods such as MIRD and direct method using TLD. The aim of this study is using TLD and a phantom to determine...

In collaboration with the MIRD Committee, Society of Nuclear Medicine: E.E. Watson (Chair), J.S. Robertson (Task Group Leader), W.E. Bolch, A.B. Brill, N.D. Charkes, D.R. Fisher, M.T. Hays, R.W. Howell, J.A. Siegel, S.R. Thomas and B.W. Wessels Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida; Gaithersburg, Maryland; Department of Radiology, George...

Abstract Background Patients with metastatic, castration-resistant prostate cancer (mCRPC) present an increased tumor burden in the skeleton. For these patients, Lutetium-177 (Lu-177) radioligand therapy targeting prostate-specific membrane antigen (PSMA) has gained increasing interest promising outcome data. Patient-individualized dosimetry enables improvement of success aim minimizing absorbe...

Introduction: Stereotactic Gamma Knife radiosurgery has been widely used for treating brain tumors. The scattered radiation outside of treatment field (peripheral dose) can induce the secondary cancer to specific organ. This paper investigated the absorbed dose to eyes, thyroid, heart, lung, breast and colon using a Monte Carlo technique for Mird phantom. We also study the ef...

introduction: radioactive materials deliver internal radiation dose to patients in nuclear medicine. manual internal radiation dose assessment is a complicated method. introduction of a simple dose calculation software is the main goal of the present study. methods: using the best current data in internal dose calculation (s-factors) recommended by icrp and by considering other technical metho...

BACKGROUND Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 (18F) Injection in six healthy volunteers (HVs), four males and two females, up to approximately 5 h post-injection. For each subject, key organs and tissues were delineated and analytical fits were made to the image data as functions of time to yield...

The development of novel, systemically administered radionuclide therapies (such as radioimmunotherapy) relies on the ability to predict dose-limiting toxicity to normal tissue. Where the kidney is the principal route of excretion of the radionuclide preparation and/or breakdown of products, nephrotoxicity may be the dose-limiting factor. Until recently, conventional (MIRD) dosimetry assumed th...

BACKGROUND AND PURPOSE We assessed the contribution of antibody internalization in the efficacy and toxicity of intraperitoneal α-radioimmunotherapy (RIT) of small volume carcinomatosis using (212)Pb-labeled monoclonal antibodies (mAbs) that target HER2 (internalizing) or CEA (non-internalizing) receptors. MATERIALS AND METHODS Athymic nude mice bearing 2-3 mm intraperitoneal tumor xenografts...