A heavy load drop into the spent fuel pool, or onto the spent fuel pool wall, can affect the structural integrity of the spent fuel pool. A loss-of-inventory from the spent fuel pool could occur as a result of a heavy load drop. The staff evaluated heavy loads as Generic Technical Activity A-36, which resulted in the publication of NUREG-0612 [Ref. 1]. Cask handling is expected to be the domina...

The cytoplasmic domain of the human type I IFN receptor chain 2 (IFNAR2c or IFN-alphaRbetaL) was used as bait in a yeast two-hybrid system to identify novel proteins interacting with this region of the receptor. We report here a specific interaction between the cytoplasmic domain of IFN-alphaRbetaL and a previously identified protein, RACK-1 (receptor for activated C kinase). Using GST fusion p...

background: noise is one of the annoying agents in the environment and it is harmful agent in workplaces that its occurrence with work load, there are in many workstations. the aim of this study was to determine the combined effects of exposure to noise and work load on heart rate changes. methods: this cross-sectional study performed on 14 male students into climatic chamber in 2011.the mean ±...

Protein kinase C (PKC), a family of at least eleven isoforms, mediates numerous cell functions. In human melanocytes, alpha, beta, delta, epsilon and zeta isoforms of PKC are expressed, but uniquely PKC-beta activates tyrosinase, the key and the rate-limiting enzyme in melanogenesis, by phosphorylating specific serine residues on its cytoplasmic domain. To investigate the mechanism by which onl...

In this paper we investigate the problem of simultaneously allocating orders and mobile storage racks to static pickers. Here are allocated pickers enable them pick all products for that have been them. Problems type considered here arise in facilities operating as robotic fulfilment systems. We present a formulation an integer program discuss complexity problem. two heuristics (matheuristics) ...

pollution of water and soils by heavy metals is an emerging problem in industrialized countries.the present study was conducted to investigate the heavy metals concentration in water and sedimentsamples from ship breaking sites of sitakunda to assess the potential ecological risk posed by heavy metalusing different methods. heavy metals concentration was analyzed by atomic absorption spectrosco...

Protein kinase C (PKC) isozymes comprise a family of related enzymes that play a central role in many intracellular eukaryotic signaling events. Isozyme specificity is mediated by association of each PKC isozyme with specific anchoring proteins, termed RACKs. The C2 domain of betaPKC contains at least part of the RACK-binding sites. Because the C2 domain contains also a RACK-like sequence (term...