We report the molecular cloning and characterization of a 49-kDa form of casein kinase I from rat testis. A cDNA clone encoding the enzyme, designated casein kinase I delta, contained an open reading frame of 1284 nucleotides that predicts a polypeptide of 428 amino acids with a M(r) of 49,121. The predicted amino acid sequence shares 76% identity with casein kinase I alpha, a 37-kDa form recen...

Unilateral paralysis of the diaphragm, not the result of a deliberate operative procedure, is uncommon. It may have a variety of causes, but so far as I am aware pneumonia* has never previously been included amongst them. The commoner causes of unilateral paralysis are diseases of the cervical spinal cord affecting the anterior horn cells of the fourth segment, such as poliomyelitis, tumour, pr...

Immun. 65, 2396 (1997). 7. N. H. Salzman, D. Ghosh, K. M. Huttner, Y. Paterson, C. L. Bevins, Nature 422, 522 (2003). 8. B. Ericksen, Z. Wu, W. Lu, R. I. Lehrer, Antimicrob. Agents Chemother. 49, 269 (2005). 9. N. H. Salzman et al., Nat. Immunol. 11, 76 (2010). 10. See supplementary materials on Science Online. 11. A. J. Bäumler, R. M. Tsolis, P. J. Valentine, T. A. Ficht, F. Heffron, Infect. I...

Abizaid, A., Liu, Z.W., Andrews, Z.B., et al. (2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. Journal of clinical Investigation, 116, 3229–3239. Ahima, R.S., Prabakaran, D., Mantzoros, C., et al. (1996) Role of leptin in the neuroendocrine response to fasting. Nature, 382, 250–252. [A seminal piece of work which establ...

i. Lfltrastructurai and biochemical changes occurring in mitochondria of skeletal muscil: of vitamin E deficient rabbits and the extent of repair of the mitochondria after oral administration of the vitamin to the deficient rabbits have been studied. 2. Muscle of the dystrophic rabbits showed structural changes typtcai of the myopathic state. and these were reversed in the rehabilitated rabbits...

This paper investigates the enhancement of power system stability via coordinated design of Power System Stabilizers (PSSs), Thyristor Controlled Series Capacitor (TCSC)-based stabilizer, and Static Var Compensator (SVC)-based stabilizer in a multi-machine power system. The design problem of the proposed stabilizers is formulated as an optimization problem. Using the developed linearized power ...

•Formerly redlined neighborhoods receive fewer rebates and have electric vehicles•Latino-majority ZIP codes the lowest vehicle penetration rebates•Racial disparities exist across all incomes for adoption•Disparities in rebate allocation exceed Passenger vehicles are an essential form of transportation contribute significantly to greenhouse gas emissions criteria air pollution. The health climat...

s of the 214th ACS National Meeting.20. Dong, J., S. Iuchi, H. S. Kwan, Z. Lu, and E. C. Lin. 1993. The deducedamino-acid sequence of the cloned cpxR gene suggests the protein is thecognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli. Gene 136:227–230.21. Dziejman, M., and J. J. Mekalanos. 1995. Two-component signal ...

•IFNγ and attachment-independent growth promote IDO1 expression in PDAC cells•Metabolism of tryptophan by contributes one-carbons to the THF cycle•Tryptophan can substitute for serine as a one-carbon source•Serine glycine restriction enhances anti-tumor activity an inhibitor Cancer cells adapt their metabolism support elevated energetic anabolic demands proliferation. Folate-dependent is critic...

The use of a human protein such as plasma-derived butyrylcholinesterase (huBuChE) to neutralize the toxic effects of nerve agents in vivo has previously been shown to provide both survival in guinea pigs and nonhuman primates and protection against decreased cognitive function in guinea pigs following exposure to a cumulative challenge of 5.5 LD50 of soman. Subsequently, a recombinant form of h...