This study evaluated the efficacy of a stepwise regimen of estradiol valerate for height control in girls with Marfan syndrome. Eight girls with Marfan syndrome who had completed estrogen treatment for height control were included. Estradiol valerate was started at a dose of 2 mg/day, and then was increased. The projected final height was estimated using the initial height percentile (on a dise...

BACKGROUND In patients with bicuspid aortic valve and dilated proximal ascending aorta, we sought to assess (1) factors associated with increased longer-term cardiovascular mortality and (2) incremental prognostic use of indexing aortic root to patient height. METHODS AND RESULTS We studied 969 consecutive bicuspid aortic valve patients (50±13 years; 87% men) with proximal aorta ≥4 cm, who al...

PURPOSE There is controversy surrounding the growth outcomes of treatment with gonadotropin-releasing hormone agonist (GnRHa) in central precocious puberty (CPP). We analyzed height preservation after treatment with GnRHa with and without growth hormone (GH) in girls with CPP. METHODS We reviewed the medical records of 82 girls with idiopathic CPP who had been treated with GnRHa at Severance ...

BACKGROUND Drug-coated balloons are rapidly emerging as a therapeutic alternative for the interventional treatment of peripheral vascular disease. The purpose of this study was to test the hypothesis that an angioplasty balloon coated with the mTOR inhibitor zotarolimus (ZCB) would inhibit neointimal hyperplasia in a novel injury-based superficial femoral artery model in the familial hyperchole...

Hypertension is more common among people who had low birthweight. Birthweight depends on the mothers body size and on the growth of the placenta. We studied a group of 2003 subjects, of whom 644 were being treated for hypertension. They were born during 1934-44 in a hospital that kept detailed records of maternal and placental size. Hypertension was associated with reduced placental weight and ...

OBJECTIVES To determine the activity of the upper trapezius, serratus anterior, anterior deltoid, biceps brachii. and lower trapezius muscles in healthy adults during below-the-knee assembly work. METHODS Fifteen right-handed male subjects participated in this study. The electrical activities, measured by EMG, of the right upper trapezius, serratus anterior, anterior deltoid, biceps brachii. ...

Marconi Soares Barbosa, Rinaldo Wander Montalvão, Tom Blundell and Luciano da Fontoura Costa Institute of Physics at São Carlos, University of São Paulo, São Carlos, SP, PO Box 369, 13560-970, Phone +55 16 3373 9858, FAX +55 162 71 3616, Brazil, [email protected] and Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, Phone +44 1223 333 628, FAX +44...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 4.5 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 96 7.9 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88 7.3 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 8.0 20 to 24 years . . . . . . . . . . . . . . . . . . . . . . ....

Goalball is a Paralympic sport exclusively for athletes who are visually impaired and blind. The aims of this study were twofold: to describe game performance of elite male goalball players based upon the degree of visual impairment, and to determine if game performance was related to anthropometric characteristics of elite male goalball players. The study sample consisted of 44 male goalball a...

BACKGROUND Turner syndrome accounts for 15-20% of childhood usage of growth hormone (GH) in the UK but final height benefit remains uncertain. The most effective strategy for oestrogen replacement is also unclear. METHODS Fifty eight girls who, at start of treatment, were of mean age 9.1 years and projected final height 142.2 cm were randomised to receive in year 1, either low dose ethinyloes...