Identifying protein targets for a bioactive compound is critical in drug discovery. Molecular similarity is a main approach to fish drug targets, and is based upon an axiom that similar compounds may have the same targets. The molecular structural similarity of a compound and the ligand of a known target can be gauged in topological (2D), steric (3D) or static (pharmacophoric) metric. The topol...

Hypersonic endoatmospheric interceptors are presently under serious consideration for strategic and theater missile defenses. On board infrared seekers are planned for terminal guidance. It is desirable to perform seeker trade studies determining such things as expected S/N, tracking performance and optimum wavelength of operation. The dynamics of the interceptor/target trajectories combine wit...

Organizations are becoming more creative in incorporating technologies to aid their businesses, for example, by building collaboration networks with customers for innovative ideas and by utilizing online communities to mobilize knowledge among their employees. In my dissertation, I examine how such networks among employees or customers empowered by information technology influence the way organ...

A Redirection Botnet (RBnet) is a vast collection of compromised computers (called bots) used as a redirection/proxy infrastructure and under the control of a botmaster. We present the design, implementation and evaluation of a system called Redirection Botnet Seeker (RB-Seeker) for automatic detection of RBnets by utilizing three cooperating subsystems. Two of the subsystems are used to genera...

provided the original work is properly cited. CC Central venous catheterization is frequently used as the procedure for preparation of major surgery, chemotherapy, total parenteral nutrition, and etc [1]. Usually, the catheterization sites are femoral vein, subclavian vein, and internal jugular vein (IJV). Because the right IJV has easy accessibility, and it gives direct route for right atrium ...