To the Editor: Kobold et al. (1) describe candidate reference methods for hemoglobin A1c (HbA1c) that are based on the identification of hexapeptides from the N-terminus of the b-chains by both a mass spectrometry technique and capillary electrophoresis. Although they are to be congratulated on their efforts in this regard, I wonder whether the (IFCC) definition of HbA1c as hemoglobin modified ...

RESULTSdEPCs were significantly reduced in T1DM children versus CO (609 6 359 vs. 1,165 6 484, P , 0.001). Multivariate regression modeling revealed that glycated hemoglobin A1c (HbA1c) was the strongest independent predictor of EPCs (b =20.355, P, 0.001). Overall glycemic control at the beginning and end of study did not differ (7.86 1.2 vs. 7.86 1.2 relative %, P = NS), but we observed indivi...

We have investigated the relationship between fetal hemoglobin (HbF) levels and metabolic control in subjects with insulin-dependent (N = 79) and non-insulin-dependent diabetes mellitus (N = 242). HbF and hemoglobin A1c (HbA1c) levels were increased in subjects with type 1 and type 2 diabetes as compared to levels in nondiabetic individuals (P < 0.0001), and were significantly higher in type 1 ...

OBJECTIVE This study investigated the use of the estimated average glucose to fasting plasma glucose ratio (eAG/fPG ratio) to screen for β-cell function in pediatric diabetes. METHODS Glycated hemoglobin (HbA1c), glycated albumin (GA), fructosamine, insulin, and C-peptide levels were measured. The ratio of GA to HbA1c (GA/A1c ratio) was calculated, and the homeostasis model assessment of β-ce...

Non-human primates (NHPs) are a very valuable experimental model for diabetes research studies including experimental pancreatic islet transplantation. In particular NHPs are the recipients of choice to validate pigs as possible source of pancreatic islets. The aim of this study was to quantify glycated hemoglobin percentage in NHPs and to assess whether changes in values reflect the metabolic ...

OBJECTIVE The level of hemoglobin A1c (HbA1c), also known as glycated hemoglobin, determines how well a patient's blood glucose level has been controlled over the previous 8-12 weeks. HbA1c levels help patients and doctors understand whether a particular diabetes treatment is working and whether adjustments need to be made to the treatment. Because the HbA1c level is a marker of blood glucose f...

Abstract Introduction Complete blood count parameters have gained renewed interest as predictors of endothelial dysfunction in type 2 diabetes mellitus (T2DM). Thus, the aim this study was to observe changes platelet and erythrocyte between diabetics nondiabetics evaluate these relation glycemic control. Materials Methods This cross-sectional performed Mohammed VI University Hospital, Marrakech...

Abstract Background Hemoglobin A1c (HbA1c; glycosylated hemoglobin) is used for diagnosis and monitoring of patients with diabetes. In the clinical laboratory both immunoassays high-performance liquid chromatography (HPLC) based tests are available such measurement. We use Premier Hb9210 analyzer (HPLC method; Trinity Biotech, Jamestown, NY) measuring HBA1c in whole blood. As our transitioning ...