Splenectomy can treat conditions characterized by hemolysis or thrombocytopenia caused autoantibodies splenic reticuloendothelial function, as well disorders massive splenomegaly and hypersplenism with cytopenias, such hereditary spherocytosis, transfusion-dependent thalassemia, immune thrombocytopenia, autoimmune hemolytic anemia, marginal zone lymph is no longer used for Hodgkin disease stagi...

aeromonas hydrophila secretes several extracellular proteins including enterotoxin, hemolysin and aerolysin that are associated with the bacterial virulence. previous studies have shown that two hemolytic toxins, hemolysin a and aerolysin a contribute to the virulence of aeromonas hydrophila. in the current study, a total of 50 strains of aeromonas hydrophila, including 28 (56%) strains isolate...

Wilson's disease (WD) is a rare inherited disorder of copper metabolism and the main manifestations are liver and brain disorders. Hemolytic anemia is an unusual complication of WD. We describe a 15-year-old girl who developed hemolytic anemia as the first manifestation of Wilson's disease. An Arg952Lys mutation was found in exon 12 of the ATP7B gene, which is uncommon among Chinese Han individ...

Atypical Hemolytic Uremic syndrome is disease that could results in end stage renal disease and subsequently requiring hemodialysis or renal transplant. It also could recur after renal transplant, which poses a challenge to diagnose and treat given the complexity of immunosuppressive medications. Proper preparation before the transplant and vigilant post transplant monitoring is crucial to pres...

Blueberry muffin rash is a characteristic multiple bluish skin nodules associated with perinatal infection, severe and chronic anemia, and neoplastic infiltrative diseases. We present an unusually severe case of hemolytic disease of the newborn. He required exchange transfusions for several times. The complete work up led to the diagnosis of anti-Cw. The skin lesion regressed spontaneously with...

Studies in this laboratory for the past several years have been focused on the epidemiology of hemolytic streptococcal disease in New Haven. Attention is being given to the incidence and possible clinical and epidemiological significance of the various serological types of hemolytic streptococci recovered from residents of this city. Current experience indicates that in a city of some 160,000 i...

Brucellosis is a worldwide zoonotic disease associated with hemolytic complications, including thrombotic microangiopathy (TMA) and hemolytic anemia. Autoimmune hemolytic anemia (AIHA) is a rare clinical presentation of this disease. In this report, we describe the cases of two patients with brucellosis who presented with Coombs-positive AIHA. We also include a review of the literature on the h...

The classification of autoimmune hemolytic anemias and the complement system are reviewed. In autoimmune hemolytic anemia of the warm antibody type, complement-mediated cell lysis is clinically relevant in a proportion of the patients but is hardly essential for hemolysis in most patients. Cold antibody-mediated autoimmune hemolytic anemias (primary cold agglutinin disease, secondary cold agglu...

INTRODUCTION Studies on the carriage rate of beta-hemolytic streptococci among children form an important component of public health practice to prevent disease complications such as rheumatic fever/rheumatic heart disease, nephritis, and other local or systemic infections. METHODOLOGY Throat swabs collected from asymptomatic schoolchildren were inoculated into appropriate media for isolation...

Compound heterozygosity for βS/βD results in a severe hemolytic anemia and a clinical syndrome similar to that of sickle cell disease. Here, we report a case of HbSD Punjab disease. A 10 year old female child residing at Nagpur, Maharashtra presented with severe hemolytic anemia, hepatosplenomegaly and occasional pains in bones and abdomen. Initially, she was thought to be a case of sickle cell...