Hemophilia is a rare disorder that is complex to diagnose and to manage. These evidence-based guidelines offer practical recommendations on the diagnosis and general management of hemophilia, as well as the management of complications including musculoskeletal issues, inhibitors, and transfusion-transmitted infections. By compiling these guidelines, the World Federation of Hemophilia aims to as...

BACKGROUND The high mutational heterogeneity of hemophilia A is a challenge for the provision of genetic services. We plan to identify the mutation in patients with hemophilia A in order to create a confidential national database of mutations for the optimization of genetic services in Italy. DESIGN AND METHODS The factor VIII gene (F8) was analyzed in 1296 unrelated patients with hemophilia ...

BACKGROUND Platelets are an underappreciated factor in the classification of the bleeding tendency of patients with hemophilia. In this cross-sectional study, we investigated platelet activation status and responsiveness in relation to residual factor VIII activity and, within the group with severe hemophilia (<1% residual factor VIII activity), to annual factor VIII consumption. DESIGN AND M...

Background: Hemophilia is a chronic bleeding disease and can interfere with daily performance of children. These children require continuous training to prevent bleeding. Since children nurses play an important role in the education of sick children and their self-efficacy and the increase use of educational computer games, the use of educational games for teaching self-efficacy to children wit...

Although immune tolerance induction (ITI) has been used for 30 years to eliminate inhibitors and restore normal factor pharmacokinetics in patients with hemophilia, there is a paucity of scientific evidence to guide therapeutic decision-making. In an effort to provide direction for physicians and hemophilia treatment center staff members, an international panel of hemophilia opinion leaders met...

Hemophilia A, B are X-linked recessive bleeding disorder that typically results from a deficiency of clotting factor VIII (FVIII) and IX (FIX). The severity the disease is determined according to FVIII FIX levels. A have similar symptoms both characterized by bleeding, particularly in large joints such as ankles, knees, elbows. Recurrent eventually causes progressive hemophilic arthropathy. Lif...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Hemophilia is a bleeding disorder. Although the incidence of hemophilia is very low, the World Foundation of Hemophilia (founded in 1963) has used a multidisciplinary approach to focus its efforts to improve care for patients with the disease worldwide. In K...

Hemophilia A is a worldwide disorder of coagulation system. It is a male disorder, yet females with hemophilia are rarely seen in communities with high rate of consanguineous marriages. The abnormalities in factor VIII gene transfer as an X-linked pattern in the family, affects as many as one-third of patients who had no family history of abnormality and thus the occurrence of a sporadic mutati...

Background: Hemophilia A and B are the most frequent congenital coagulation disorders. This study was conducted to determine the prevalence of hepatitis B, C and human immunodeficiency viruses among hemophilic patients in Hamadan, Iran. Patients and Methods: In this study, patients with hemophilia A and B treated in Hamedan Hemophilia Center, Hamedan, Iran, were screened for hepatitis B, C and...

As hemophilia is a chronic bleeding diseaseand can interfere with daily performanceof children, these children require continuoustraining to prevent bleeding and take timely action(1). Since children nurses play an important role inthe education of involved children and their Selfefficacyand also due to today’s approach whichis using educational computer games, the use ofeducational games in re...