Iron is an essential element for the living body. The human body stores iron mostly in liver, spleen, marrow and skeletal muscle in the form of ferritin and hemosiderin. Hemosiderin has been known as yellowish granules that can be stained by Prussian blue in the tissue cells. On the other hand, ferritin is invisible by photomicroscopy or may be faintly visible and stained diffusely in the tissu...

PURPOSE To quantify the two principal forms of hepatic storage iron, diffuse, soluble iron (primarily ferritin), and aggregated, insoluble iron (primarily hemosiderin) using a new MRI method in patients with transfusional iron overload. MATERIALS AND METHODS Six healthy volunteers and 20 patients with transfusion-dependent thalassemia syndromes and iron overload were examined. Ferritin- and h...

Remarkable progress was recently achieved in the studies on molecular regulators of iron metabolism. Among the main regulators, storage iron, iron absorption, erythropoiesis and hepcidin interact in keeping iron homeostasis. Diseases with gene-mutations resulting in iron overload, iron deficiency, and local iron deposition have been introduced in relation to the regulators of storage iron metab...

BACKGROUND AND PURPOSE Intractable epilepsy is a well-recognized complication following head trauma, and many factors have been implicated in its pathogenesis. This study was performed to determine the severity of tissue damage after severe head injury as assessed with magnetization transfer (MT) MR imaging and the relationship of this damage with seizure intractability. METHODS Forty-four pa...

With great interest, we read the recent work by Fujii et al. (1) published in iJACC reporting the diagnostic accuracy of optical coherence tomography (OCT) and grayscale intravascular ultrasound for the detection of coronary thin cap fibroatheroma (TCFA) with histologic validation in human autopsy hearts. In this publication, Fujii et al. (1) documented a limited capability of OCT and intravasc...

Iron is stored in tissues as ferritin and hemosiderin. These compounds are increased in a state of iron excess and become depleted with iron deficiency (2). Both may be considered to represent iron reserves which may be mobilized when needed. The functional relationship between these two compounds has been a matter of speculation. It has been suggested that the ferritin fraction represents more...

BACKGROUND The purpose of this study was to determine whether the SWI sequence may improve the MRI evaluation of hemosiderin deposits in the brain. CASE REPORT We report a case of a 7-year-old girl after a total resection of a large tumor mass (ependymoma G II) located in the left hemisphere. Late complication of surgery was hemosiderosis of the brain diagnosed with SWI sequence. CONCLUSION...