R.J. Hay, Department of Dermatology, Guys Hospital, London SE1 9RT, London, UK The present comprehensive range of antifungal drugs used in the treatment of superficial mycoses is by no means ideal. There are, for instance, certain infections which are refractory to existing therapy such as chronic tinea pedis due to Trichophyton rubrum, which has a 60–70% relapse rate whatever the primary thera...

OBJECTIVE A previous study demonstrated that non-anthracycline-containing docetaxel plus cyclophosphamide (TC) regimen was inferior to docetaxel, anthracycline and cyclophosphamide (TAC) in neoadjuvant treatment of triple-negative breast cancer (TNBC) and human epidermal growth factor receptor-2-(HER2)-positive breast cancer in a short-term follow-up. Herein, long-term follow-up survival outcom...

Persons who are subject to care due to suicidal thoughts and/or acts, are in a vulnerable situation, struggling with issues related to life and death as well as experiences of hopelessness and powerlessness. They may also experience themselves as a burden for their relatives. The relatives’ struggle for contributing to the loved person’s survival, can involve experiences of taking responsibilit...

Anaesth 2015; 114: 297–306 18. Natt BS, Malo J, Hypes CD, Sakles JC, Mosier JM. Strategies to improve first attempt success at intubation in critically ill patients. Br J Anaesth 2016; 117(Suppl. 1): i60–i68 19. Mercer SJ, Jones CP, Bridge M, Clitheroe E, Morton B, Groom P. Systematic review of the anaesthetic management of noniatrogenic acute adult airway trauma. Br J Anaesth 2016; 117 (Suppl....

In the present study, the receptor binding potential oftransferrin (Tf) was linked to an antibody binding specificity. Human Tf was fused to mouse-human chimeric IgG3 at three positions: at the end of heavy chain constant region 1 (CHi), after the hinge, and after CH3. The resulting Tf-antibody fusion proteins were able to bind antigen and the Tf receptor. The CH3-Tf fusion protein showed no co...

In the world of CAD and GIS there is a growing need for storing spatial information in neutral contexts. Storing the information in a database rather than in files gives rise to greater options concerning what can be done with the information. Being able to perform analyses on spatial information is an area of interest for many companies. In particular since analyses provide foundations for pla...

In vitro metabolism and metabolic activation of 2-acetylaminofluorene (AAF), 2-aminofluorene, and 2,4-diaminoanisole to mutagenic (Salmonella test system) and covalently proteinbound intermediates were evaluated in subcellular fractions from seven human livers. The cytochrome P-450 content, aryl hydrocarbon hydroxylase activity, and sodium dodecyl sulfate: polyacrylamide gel electrophoresis of ...

In vitro metabolism and metabolic activation of 2-acetylaminofluorene (AAF), 2-aminofluorene, and 2,4-diaminoanisole to mutagenic (Salmonella test system) and covalently proteinbound intermediates were evaluated in subcellular fractions from seven human livers. The cytochrome P-450 content, aryl hydrocarbon hydroxylase activity, and sodium dodecyl sulfate: polyacrylamide gel electrophoresis of ...

Growing anthropogenic pressures on ecosystems mean that global biodiversity is being threatened in ways have no precedent historical times (Blowes et al., 2019; Isbell 2017; Magurran & Dornelas, 2010). Landscape transformation, including appropriating natural habitat for crop use, viewed as a major contributor to this ongoing crisis (Ehrlich Pringle, 2008; Semper-Pascual 2019). Habitat transfor...