heparin was isolated from whole clam tissue marcia opima . purification of multimilligram quantities of heparin from this tissue sample permitted a thorough examination of its anticoagulant activity characterization, which was partially purified by fractionation by anion exchange chromatography using deae cellulose column. the isolated crude and partially purified fractionated sample showed met...

background:   objective: to investigate the association between thrombophilia and unexplained recurrent miscarriage and to evaluate the efficacy of anticoagulant treatment.   materials and methods: in this quasi experimental, we enrolled 520 women, who had a history of recurrent miscarriage. two hundred fifty two women with unexplained recurrent miscarriage were assigned to receive aspirin (80 ...

Objective- Study on the effect of heparin in prevention of abdominal adhesions following abdominal surgery in rat. Design- Experimental design. Animals-Twenty male rats with average weight of 248 ± 5 gr. Procedures- Animals were randomly divided into two equal groups of 10 rats (A and B). After induction of anesthesia, a midline abdominal incision was made and intestines were manipulated ...

Background: Coronary angiography consists of the selective injection of contrast agents in coronary arteries. Optimal strategy for heparin administration during coronary angiography has yet to be determined. We assessed the effect of heparin administration during coronary angiography on vascular, hemorrhagic, and ischemic complications.Methods: Five hundred candiates for diagnostic coronary ang...

A 66-year-old woman presented with painful abdominal skin necrosis where she had been injecting subcutaneous enoxaparin 1 week following elective knee arthroplasty (Figure). Her complete blood cell count and basic metabolic panel yielded unremarkable findings. Enoxaparin was discontinued, a direct thrombin inhibitor started. Heparin platelet factor 4 IgG antibody strongly positive (2.065 OD), a...

background and objective: bruising is the most common complications that resulting from subcutaneous heparin injection. it causes the limitation of injection area, anxiety, disruption of body image, refusing treatment in patients and the reduction in patients trust in nurse. although different methods were suggested to lessen these unwanted complications, unfortunately none of them could decrea...

Heparin-induced thrombocytopenia (HIT) has not been included as a possible cause of in Coronavirus Disease 2019 (COVID-19) patients. We report case HIT patient with COVID-19 treated heparin. A 78-year-old man was admitted to our hospital for acute respiratory failure and renal due SARS-CoV-2 infection; intensive care unit, one 5000 IU heparin dose (day 0, platelet count 305,000/?L). On day 2, h...

background deep venous thrombosis (dvt) is a major risk of morbidity and mortality in morbid obese patients underwent bariatric surgery. there are some controversies in different kind of prophylactic strategies for dvt in laparoscopic bariatric surgeries. unfractionated heparin (ufh) is an available and reversible anticoagulant used for dvt prophylaxis. objectives this study aimed to compare cl...

background: the objective of this study is to optimize the effective dose of heparin and ligustrazine hydrochloride injection (lhi) for drug combination. materials and methods: the animal clinical study of lhi was performed by the rat’s model of induced arteriovenous shunt thrombosis. experimental animals were grouped into several groups and separately treated with both lhi (20, 40, 80 mg/kg, i...