objective(s): to appraise the antihepatotoxic efficacy of ethanolic extract of operculum turpethum root on the liver of swiss albino mice.   materials and methods:   hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of n-nitrosodimethylamine (ndma) at the concentration of 10 mg/kg body weight. the liver toxicity and therapeutic effect of the plant et...

Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood. However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing in older adults. Poor understanding of how hepatic clearance and toxicity are different with age r...

AMD chronic administration induces hepatic lipid accumulation by several mechanisms, including induction of ER stress, impairment β-oxidation, and inhibition triacylglycerol secretion. Our study shows that repetitive treatment not only stress but also adipose tissue lipolysis free fatty acids enrichment palmitate in the total lipids. Understanding toxicity mechanisms would help devise ways to l...

Background: Workers in different occupational positions experience significant Cu exposures, however, Cu toxicity has not been fully studied as compared to other heavy metals. In the present study, hematological and hepatic alterations have been investigated among copper mine workers. Materials and Methods: This descriptive study was conducted in a copper mine in west of Iran, on 402 copper mi...

Cadmium (Cd) is a highly toxic heavy metal, wide occupational and an environmental pollutant, affecting human health. Probiotics especially lactic acid bacteria (LAB) have the capacity to bind, remove and to decrease tissue cadmium levels. The objective was to evaluate the potency of Cd binding capacity, antioxidative properties of probiotic bacteria against cadmium in vitro and its probable de...

Interleukin 2 (IL-2) mediates the regression of metastatic cancer, but its clinical use is limited by associated toxicities including hepatic dysfunction. To determine the mechanism for IL-2-induced hepatic dysfunction, we hypothesized that IL-2 activation of Kupffer cells causes leukocyte-endothelial adhesion and decreases hepatic sinusoidal blood flow. C57BL/6 mice were given injections of la...

conclusions hepatotoxicity of halogenated inhalational anesthetics has been well documented in available literature. halothane-induced liver injury was extensively acknowledged; however, the next generation halogenated anesthetics have different molecular structures and associated with less hepatotoxicity. although anesthesia-induced hepatitis is not a common occurrence, we must consider the as...

Cadmium (Cd) is a highly toxic heavy metal, wide occupational and an environmental pollutant, affecting human health. Probiotics especially lactic acid bacteria (LAB) have the capacity to bind, remove and to decrease tissue cadmium levels. The objective was to evaluate the potency of Cd binding capacity, antioxidative properties of probiotic bacteria against cadmium in vitro and its probable de...