OBJECTIVE To explore the expression of RECK and relevant matrix metalloproteinases (MMPs) in hepatoblastoma (HB) and neuroblastoma (NB) and their clinical significance in the tumor metastasis. MATERIALS AND METHODS Forty-five wax-stone samples of HB and 43 wax-stone samples of NB removed by surgical resection and confirmed by pathology in Linyi Yishui Central Hospital were selected. According...

Hepatoblastoma (HB) is a common type of primary tumor in children. Previous studies have examined the expression of genes, including transcription factors (TFs), target genes, host genes and microRNAs (miRNAs or miRs) associated with HB. However, the regulatory pathways of miRNAs and genes remain unclear. In the present study, a novel perspective is proposed, which focuses on HB and the associa...

The response of standard-risk hepatoblastoma (HB) to neoadjuvant cisplatin (CDDP) chemotherapy is excellent; however, in high-risk HB, drug resistance remains a major challenge. Alternative therapeutic strategies may consider combining cytotoxic drugs with apoptosis sensitizers as this has shown additive effects in various types of malignancies. Analysis of published expression databases have r...

OBJECTIVES Hepatoblastoma (HB) is the most common pediatric liver malignancy, typically affecting children within the first 4 years of life. However, only a few validated blood biomarkers are used in clinical evaluation. The current study explored the clinical application and significance of D-dimer levels in patients with HB. METHOD Forty-four patients with HB were included in this retrospec...

Pediatric hepatoblastoma (HB) is commonly treated by neoadjuvant chemotherapy and surgical tumor resection according to international multicenter trial protocols. Complete tumor resection is essential and survival rates up to 95% have now been achieved in those tumors classified as standard-risk HB. Drug resistance and occurrence of metastases remain the major challenges in the treatment of HB,...

Hepatoblastoma (HB), the most common childhood liver cancer, is associated with seven distinct histologic subtypes and variable degrees of clinical aggressiveness presentation. Yet it among least genomically altered tumors known, about half HBs showing mutation and/or dysregulation Wnt/?-catenin Hippo pathways. This raises question how this mutational simplicity can generate such biological com...

OBJECTIVE This study aimed to investigate the effect of multimodality treatment of advanced paediatric hepatoblastoma (HB) and the factors affecting prognosis. METHODS A total of 35 children underwent multimodality treatments consisting of chemotherapy, surgery, interventional therapy, and autologous peripheral blood stem cell transplantation. The patients were followed up every month. RESU...

The aim of this study was to analyze the clinical efficacy, prognosis, and risk factors of surgery combined with chemotherapy in treating Hepatoblastoma (HB). A total of 102 HB patients diagnosed and enrolled in Beijing Tongren Hospital from September 2006 to June 2014 were included in this study. Clinical stage of HB was determined according to the Post-surgical staging system of the Children ...

PURPOSE The aim of this study is to evaluate our experience at the NCI, Cairo University in the management of non- metastetic hepatoblastoma (HB). Also to improve survival of children with HB and reduce the operative morbidity and mortality by using preoperative chemotherapy. PATIENTS AND METHODS After biopsy and assessment of the extent of disease, all patients were treated with a 6-hour con...

Although formalin fixed paraffin embedded (FFPE) tissue is a major biological source in cancer research, it is challenging to work with due to macromolecular fragmentation and nucleic acid crosslinking. Therefore, it is important to characterise the quality of data that can be obtained from FFPE samples. We have compared three independent platforms (next generation sequencing, microarray and Na...