In this issue of Clinical Cancer Research , Zhang et al. (1) examined the potential for the use of epigenetic biomarkers in a noninvasive approach to early detection of hepatocellular carcinoma in a population of high-risk patients from Taiwan. Using DNA prepared from serum samples corresponding to hepatocellular carcinoma patients, but collected at various time intervals before the diagnosis o...

Reports of epidemiological studies of liver cancer relevant to these monographs have employed a variety of terms to describe this disease, for example, lIver cancer, primary liver cancer, primary hepatocellular carcinoma and hepatocellular carcinoma. We chose to use only the term hepatoceIIular carcinoma (HCC) in describing these studies. This choice was made because most of the studies have sp...

BACKGROUND The clinical significance of miR-141-3p in hepatocellular carcinoma has not been verified. Therefore, we conducted this study to examine miR-141-3p expression and its clinical significance in hepatocellular carcinoma and to investigate the functions of its potential targets. METHODS The Cancer Genome Atlas database and the Gene Expression Omnibus database were used to explore the a...

Introduction Primary liver cancer is a significant cause of cancer-related death in both the United States and the world at large. Hepatocellular carcinoma comprises 90% of these primary liver cancers and has numerous known etiologies. Evaluation of these identified etiologies and other traditional risk factors cannot explain the high incidence rates of hepatocellular carcinoma in Texas. Texas ...

BACKGROUND The incidence of hepatocellular cancer in complicated alcoholic and non-alcoholic fatty liver diseases is on the rise in western countries as well in our country. Vascular adhesion protein-1 (VAP-1) levels have been presented as new marker. In our study protocol, we assessed the value of this serum protein, as a newly postulant biomarker for hepatocellular cancer in patients with a h...

More than 90% of all liver malignancies are hepatocellular carcinomas (HCCs), for which chemotherapy and immunotherapy the ideal therapeutic choices. Hepatocellular carcinoma is descended from other diseases, such as viral hepatitis, alcoholism, metabolic syndrome. Normal cells tissues may suffer damage common forms chemotherapy. In contrast to systemic chemotherapy, localized can reduce side e...

According to the WHO’s recently released worldwide cancer data for 2020, liver ranks sixth in morbidity and third mortality among all malignancies. Hepatocellular carcinoma (HCC), most common kind of cancer, accounts approximately 80% primary malignancies is one leading causes death globally. The intractable tumor microenvironment plays an important role development progression HCC three major ...

Background: Hepatocellular carcinoma (HCC) is the sixth greatest frequent disease in world and second biggest cause of cancer mortality men developing nations, with over 782,000 deaths globally each year, China accounting for almost half them. Aim study: The goal this research was to see whether epidermal growth factor might be used as an indicator early detection hepatocellular cancer. Patient...

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. There is growing evidence for a chemopreventive role of nutrition in the development of HCC in at risk populations. Bibliographical searches were performed in PubMed for the terms 'nutrition and hepatocellular carcinoma', 'nutrition and liver cancer', 'nutrition and hepatic cancer', 'diet and hepatocellular...