Over the past several decades, entecavir (ETV) and tenofovir disoproxil fumarate (TDF) have remained first-line antiviral agents in international guidelines. These two shown similar short to intermediateterm efficacy, including virologic, biochemical, serologic, histologic responses. However, huge controversies regarding efficacy of ETV TDF preventing development hepatocellular carcinoma (HCC) ...

The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...

hepatocellular carcinoma (hcc) represents one of the most common neoplasms worldwide.  liver trasnplantation (lt) is the treatment of choice for selected group of patients with hcc. lt is actually a consolidated therapeutic option for hcc because it cures both tumor and underlying cirrhosis. in 1996, the publication of a pivotal prospective study on less than 50 patients, transplanted for hcc u...

Background: Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule with modulatory effects on NK and T cells. Because HLA-G expression is frequently detected in different solid tumors, it may be involved in tumor immune evasion. Objective: This study was designed to elucidate the prognostic value of HLA-G in hepatocellular carcinoma (HCC) and pancreatic adenocarcinoma (PADC). Th...

Hepatocellular carcinoma (HCC) is relatively common worldwide. Until a few years ago skeletal involvement from HCC was rarely diagnosed. Thanks to novel imaging techniques and multidisciplinary treatment approaches, the overall survival in HCC patients has prolonged, and bone involvement has significantly increased currently. This short review summaries the value of bone scintigraphy in patient...

hepatocellular carcinoma (hcc) is the fifth most common tumor in the world, and its incidence is increasing. it is second most common cause of cancer related death worldwide and fastest growing cause of cancer death in the united states. cirrhosis is the most important clinical risk factor for hcc, with approximately 80% of cases of hcc developing in patients with a cirrhotic liver. hcc differs...

Oncological diseases are one of the leading health problems both in world and Kazakhstan, second only to cardiovascular diseases. Hepatocellular carcinoma occupies 8th place structure oncopathologies, has an unfavorable prognosis course. According WHO, more than 1.3 million people die each year from hepatocellular (HCC). The incidence rate HCC Kazakhstan is up 5.5 cases per 100 thousand populat...

Background: Hepatocellular carcinoma (HCC), primary liver cancer, is a major health problem and the third most common cause of cancer-related deaths worldwide. Epigenetic modulations are essential for the maintenance of gene expression patterns in mammals. Disruption of these processes can lead to silenced gene and malignant cellular transformation. The current study was designed to compare the...

Spontaneous rupture of hepatocellular carcinoma (HCC) is a potentially lethal complication. Despite various treatment modalities with curative intent, there are scant data on ruptured cases achieving complete pathological response (pCR), only handful case reports. We report Chinese male patient large advanced HCC (aHCC) first detected in an emergency setting, developing pCR after multidisciplin...

Chronic hepatitis B virus (HBV) infection has long been the most common cause of hepatocellular carcinoma (HCC). However, some aspects of the pathogenesis of HBV infection and genesis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) are still inconclusive. An increasing number of published studies indicate that hepatitis B virus mutations are associated with risk of HCC. These ...